巨噬细胞活化在PM_(2.5)致肺纤维化中的作用研究进展

Role of macrophage activation in pulmonary fibrosis induced by PM_(2.5):a review of recent studies

PM_(2.5)是大气污染物的主要成分之一,被人体吸入后可沿支气管到达肺部,分散沉积在肺泡内壁,引起肺泡上皮细胞损伤,继而诱导成纤维细胞增殖并转化为肌成纤维细胞,形成肺纤维化。肺巨噬细胞作为呼吸系统内与PM_(2.5)作用的第一道防线,具有较强的可塑性和异质性,在PM_(2.5)致纤维化的过程中起着至关重要的作用。该文通过查阅近年来国内外相关文献,对肺巨噬细胞在PM_(2.5)致肺纤维化过程中的病理作用及其研究进展作一综述,以期为肺纤维化的靶点治疗提供参考。

PM_(2.5)is one of the main components of atmospheric pollutants,inhaled by the human body can reach the lungs along the bronchus,dispersed deposition in the alveolar lining,causing alveolar epithelial cell damage.And then it can induce fibroblasts to multiply and transform into myofibroblasts,resulting in pulmonary fibrosis.As the first line of defense against PM_(2.5)in the respiratory system,pulmonary macrophages have strong plasticity and heterogeneity,and play a crucial role in the process of PM_(2.5)induced fibrosis.In this paper,the pathological role of pulmonary macrophages in the process of PM_(2.5)induced pulmonary fibrosis and its research progress were reviewed by referring to the relevant literatures at home and abroad in recent years,in order to provide the reference for the targeted treatment of pulmonary fibrosis.