高孕激素状态下促排卵在多囊卵巢综合征中应用的机制及研究进展

Mechanism and progress for progestin-primed ovarian stimulation protocol in the patients with polycystic ovary syndrome

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是女性最常见的妇科内分泌疾病之一,也是无排卵性不孕的首要原因。与正常排卵女性相比,PCOS患者在辅助生殖治疗中更易面临卵巢过度刺激综合征、卵母细胞质量差和受精失败等问题,因此PCOS患者的促排卵问题备受生殖领域的关注。高孕激素状态下促排卵(progestin-primed ovarian stimulation,PPOS)方案利用外源性孕激素有效阻断黄体生成素峰,达到理想的获卵数、胚胎质量及妊娠结局。本文就PPOS方案对PCOS患者的作用机制、临床应用及发展进行综述。

Polycystic ovary syndrome(PCOS)is one of the most common gynaecological endocrine diseases in women and the main cause of anovulatory infertility.Compared with women with normal ovulation,PCOS patients are more likely to face ovarian hyperstimulation syndrome,poor-quality of oocyte and fertilization failure in assisted reproduction treatment,so ovulation induction in PCOS patients has attracted much attention in the reproductive field.Progestin-primed ovarian stimulation(PPOS)protocol uses exogenous progesterone effectively to block luteinizing hormone surge to achieve ideal number of retrieved oocytes,embryo quality and pregnancy outcomes.This article reviews the mechanism,clinical application and development of PPOS protocol in PCOS patients.