铁死亡与睾丸功能障碍的研究进展

Advances in the study of ferroptosis and testicular dysfunction

铁稳态对人体正常生理代谢至关重要,铁代谢紊乱与多种疾病的发生、发展相关。铁死亡主要表现为细胞内铁和脂质过氧化物的积累,抗氧化系统为其主要的防御机制。研究证明铁死亡与氧化应激、男性不育密切相关,抑制铁和脂质过氧化物的积累可能是治疗铁死亡相关男性生殖疾病的一种潜在策略。近年来,铁死亡这种新型细胞死亡方式与男性生殖障碍的相关研究引起学者们的广泛关注和不断探索。故本文结合最新的研究进展,主要从铁死亡机制、铁死亡在睾丸功能中的作用、与男性不育的关系和相关男性生殖疾病的潜在治疗策略等方面阐述铁死亡对睾丸生精功能的影响,为防治男性生殖疾病拓展思路。

Iron homeostasis is essential for normal physiological metabolism in the human body,and disorders of iron metabolism are associated with the development of several diseases.Ferroptosis is mainly manifested by the accumulation of intracellular iron and lipid peroxides,with the antioxidant system as its main defense mechanism.Current studies have demonstrated that ferroptosis is closely related to oxidative stress and male infertility,and inhibiting the accumulation of iron and lipid peroxides may be a potential strategy for the treatment of ferroptosis-associated male reproductive diseases.Recently,the study of ferroptosis,a novel cell death mode,and male reproductive disorders has attracted extensive attention and continuous exploration by scholars.Therefore,this article combines the latest research progress,mainly elaborates on the effect of ferroptosis on testicular spermatogenesis,from the mechanism of iron death,the role of ferroptosis in testicular function,the relationship with male infertility,and the potential therapeutic strategies for related male reproductive diseases,to expand the ideas for the prevention and treatment of male reproductive diseases.