正中神经电刺激对脑损伤患者昏迷唤醒的研究进展

Research progress on median nerve electrical stimulation for awakening comatose patients with brain injury

随着医学的发展, 颅脑损伤患者的救治率逐渐提升, 更多的生命被成功挽救, 但因此产生的昏迷患者逐渐增多, 持续的医疗照护增加了家庭及社会的经济负担, 对昏迷患者进行促醒的意义重大。正中神经电刺激(MNS)作为一种无创的脑刺激技术, 已广泛应用于临床促醒治疗, 多项临床研究证实了此项技术的效果。本文从昏迷机制、正中神经通路、MNS的促醒机制、MNS的临床应用、电刺激的参数设置及神经功能评估等方面, 总结该技术的研究进展。

With the development of medicine,the survival rate of patients with traumatic brain injury has gradually increased,and more lives have been successfully saved.However,the number of comatose patients has also risen,leading to prolonged medical care that increases economic burdens on families and society.The awakening of comatose patients is of great significance.As a non-invasive brain stimulation technique,median nerve electrical stimulation(MNS)has been widely used in clinical awakening therapy,and multiple clinical studies have confirmed the effectiveness of this technology.This article summarizes the research progress of this technology from the aspects of coma mechanism,median nerve pathway,awakening mechanism of MNS,clinical application of MNS,parameter setting of electrical stimulation,and neurological function evaluation.