外周免疫细胞与急性缺血性卒中患者转归

Peripheral immune cells and outcome of patients with acute ischemic stroke

急性缺血性卒中发病后,神经细胞发生缺血坏死,释放内源性损伤相关模式分子,激活小胶质细胞和星形胶质细胞,进而导致免疫炎症反应。同时,吸引和趋化外周血免疫细胞通过破坏的血脑屏障浸润脑组织,进一步加重脑损伤。研究显示,外周血免疫细胞与急性缺血性卒中转归密切相关。文章总结了外周免疫细胞在缺血性脑损伤中的作用机制及其与临床转归的相关性和可能的干预措施。

After onset of acute ischemic stroke,nerve cells undergo ischemic necrosis,release endogenous damage related pattern molecules,which activate microglia and astrocytes,and lead to immune inflammatory responses.At the same time,it attracts and chemotactically guide peripheral blood immune cells to infiltrate brain tissue through the damaged blood-brain barrier,further exacerbating brain injury.Studies have shown that the peripheral blood immune cells are closely associated with the outcome of acute ischemic stroke.This article summarizes the mechanism of peripheral immune cells in ischemic brain injury,their correlation with clinical outcome,and possible intervention measures.