胶质淋巴系统在脑小血管病中的作用

Role of glymphatic system in cerebral small vascular disease

胶质淋巴系统(glymphatic system,GS)是由星形胶质细胞终足上的水通道蛋白4为结构基础的动态液体转运和物质清除系统,主要包括动脉周围间隙的脑脊液流入通路、脑实质内的脑脊液与组织间液交换通路以及静脉周围间隙的脑脊液流出通路。脑小血管病(cerebral small vessel disease,CSVD)的确切发病机制仍不明确,目前仍缺乏干预其发生或进展的有效手段。研究提示,GS与CSVD的密切相关。文章阐述了GS在CSVD中的作用,期待为CSVD的治疗寻求新的思路。

The glymphatic system(GS)is a dynamic fluid transport and material clearance system based on aquaporin 4 on the astrocytic endfeet.It mainly includes the inflow pathway of cerebrospinal fluid in the periarterial space,the exchange pathway of cerebrospinal fluid and tissue fluid in the brain parenchyma,and the outflow pathway of cerebrospinal fluid in the perivenous space.The exact pathogenesis of cerebral small vessel disease(CSVD)is still unclear.There is currently a lack of effective means to intervene in its occurrence or progression.Existing studies suggest that CSVD and GS are closely related.This article elaborates on the role of GS in CSVD and looks forward to seeking new ideas for the treatment of CSVD.