基于苯并噻唑的肼荧光探针合成与性质研究

Synthesis and Properties of Benzothiazole Derivatives Based Fluorescence Probe for Detecting Hydrazine

肼是一种重要的化工原料,但其对人体有高毒性和致癌性。本文设计合成了以苯并噻唑为荧光母核、腈基乙酸乙酯为电子受体、双键为连接体的水合肼探针HBT-Hy1,该探针具有橙红色荧光,荧光量子效率为0.36。实验结果表明:HBT-Hy1对水合肼专一性响应,Br^(-)、I^(-)、CH_(3)COO^(-)等阴离子及氧化性含氧化合物ClO^(-)和H_(2)O_(2)均不会对探针的响应产生干扰。探针与肼作用后发射光谱蓝移了80 nm,当肼的浓度为6×10^(-5)mol·L^(-1)至2.4×10^(-4)mol·L^(-1)时,荧光强度与肼浓度呈线性关系,对肼的检出限为1.4×10^(-5)mol·L^(-1)。

Hydrazine is a kind of important chemicals,but it is highly toxic to humans.In this paper,we have designed and synthesized the hydrazine hydrate probe HBT-Hy1 with benzothiazole as the fluorescent mother nucleus,nitrile-based ethyl acetate as the electron acceptor,and double bond as the linker,which has orange-red fluorescence with a fluorescence quantum efficiency of 0.36.The experimental results showed that HBT-Hy1 had good selectivity for hydrazine hydrate,and the emission spectrum blue-shifted by 80 nm after mixing with hydrazine,showing a ratio response;The linear range is 6×10^(-5)mol·L^(-1)to 2.4×10^(-4)mol·L^(-1),with a detection limit of 1.4×10^(-5)mol·L^(-1).