普瑞巴林联合盐酸乙哌立松治疗膝骨关节炎的疗效及对血清因子水平的影响研究

Study of the efficacy of pregabalin combined with eperisone hydrochloride in the treatment of knee osteoarthritis and its effects on serum factors

目的评估普瑞巴林联合盐酸乙哌立松对膝骨关节炎患者的疗效和血清因子水平的影响。方法选择2020年1月~2023年12月广西民族医院收治的64例膝骨关节炎患者为研究对象。根据抽签法分为试验组(32例)和对照组(32例),对照组接受普瑞巴林治疗,试验组接受普瑞巴林联合盐酸乙哌立松治疗。对比两组在疗效、骨关节炎指数[西安大略和麦克玛斯特大学骨关节炎指数(WOMAC)评分]、膝关节活动度、疼痛状况[视觉模拟评定量表(VAS)评分]、关节功能[美国膝关节协会评分标准(AKSS)评分]、血清因子水平[血清基质金属蛋白酶-3(MMP-3)、环氧化酶-2(COX-2)、白细胞介素-6(IL-6)]上的差异。结果治疗8周后,试验组在治疗总有效率上高于对照组(P<0.05);试验组在WOMAC评分、VAS评分上低于对照组,在膝关节活动度上大于对照组(P<0.05);试验组在AKSS评分方面高于对照组(P<0.05);试验组的MMP-3、COX-2和IL-6水平低于对照组(P<0.05)。结论普瑞巴林联合盐酸乙哌立松治疗能提高膝骨关节炎患者的疗效,改善疼痛和关节活动度,同时降低炎症标志物,显示出优于单药治疗的效果。

Objective To assess the efficacy of pregabalin combined with eperisone hydrochloride on patients with knee osteoarthritis and its impact on serum factors.Methods From January 2020 to December 2023,64 patients with knee osteoarthritis treated at Guangxi National Hospital were selected for study objectives.Patients were randomly divided into two groups by drawing lots:the control group(32 patients)and the test group(32 patients).The control group received pregabalin treatment,and the test group(32 patients)received a combination of pregabalin and eperisone hydrochloride.The study compared the differences between the two groups in terms of treatment efficacy,osteoarthritis index[Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)scores],knee joint mobility,pain condition[Visual Analogue Scale(VAS)scores],joint function[American Knee Society Score(AKSS)],and serum factor levels[matrix metalloproteinase-3(MMP-3),cyclooxygenase-2(COX-2),interleukin-6(IL-6)].Results After 8 weeks of treatment,the test group showed a higher overall efficacy rate than the control group(P<0.05);the test group had lower WOMAC scores and VAS scores,and greater knee joint mobility than the control group(P<0.05).The test group also had higher AKSS scores(P<0.05)and lower levels of MMP-3,COX-2,and IL-6 than the control group(P<0.05).Conclusion The treatment of pregabalin combined with ephedrine hydrochloride enhances the effectiveness in patients with knee osteoarthritis,improves pain and joint mobility,and reduces inflammation markers,showing superior results compared to the monotherapy.