低升糖指数饮食+运动干预对肥胖人群脂联素和胰岛素抵抗指数的影响

The Effect of Low Glycemic Index Diet+Exercise Intervention on Adiponectin and Insulin Resistance Index in Obese Population

目的探讨低升糖指数饮食+运动干预对肥胖人群脂联素和胰岛素抵抗指数的影响。方法选取东莞市南城医院2022年1月—2023年6月身体质量指数(body mass index,BMI)≥28 kg/m^(2)肥胖人群100例作为观察组,并选取同时间段BMI 18.5~24 kg/m^(2)的正常体质量人群100例作为对照组。2组均行健康检查,并比较2组的腰臀比、体脂分布百分比、脂联素、总胆固醇、三酰甘油、胰岛素、胰岛素抵抗指数的差异,同时采取Pearson法分析脂联素与各指标的相关性。对观察组展开低升糖指数饮食+运动干预,比较干预前与干预4个月后各指标的变化。结果观察组腰臀比[(1.53±0.32)vs.(0.88±0.12)]、体脂分布百分比[(36.83±7.63)%vs.(27.12±4.21)%]高于对照组,脂联素[(0.68±0.16)mg/L vs.(1.21±0.22)mg/L]低于对照组,差异有统计学意义(P<0.05)。观察组总胆固醇、三酰甘油、胰岛素、胰岛素抵抗指数均高于对照组(P<0.05)。通过Pearson法分析发现,脂联素与腰臀比、体脂分布百分比、总胆固醇、三酰甘油、胰岛素、胰岛素抵抗指数存在负相关性(P<0.05)。观察组干预后腰臀比、体脂分布百分比、总胆固醇、三酰甘油、胰岛素、胰岛素抵抗指数均低于干预前,脂联素高于干预前,差异有统计学意义(P<0.05)。结论肥胖人群与正常体质量人群相比,存在脂联素下降、胰岛素抵抗升高的特点,且脂联素与腰臀比、体脂分布百分比、总胆固醇、三酰甘油、胰岛素、胰岛素抵抗指数存在负相关性。通过低升糖指数饮食与运动干预可以改善肥胖人群的血脂水平与胰岛素抵抗状况。

Objective To explore the correlation between adiponectin,resistin and insulin resistance in obese people.Methods A total of 100 obese people with body mass index(BMI)≥28 kg/m^(2) from January 2022 to June 2023 in Dongguan Nancheng Hospital were selected as the observation group,and 100 normal weight people with BMI of 18.5-24 kg/m^(2) during the same period were selected as the control group.Health examination was performed in both groups,and the differences in waist-to-hip ratio,percentage of body fat distribution,adiponectin,resistin,total cholesterol,triglyceride,insulin and insulin resistance index were compared between the two groups.Meanwhile,Pearson method was used to analyze the correlation between adiponectin and resistin and each index.Diet+exercise intervention was carried out in the observation group,and the changes of each index were compared before intervention and 4 months after intervention.Results The waist to hip ratio[(1.53±0.32)vs.(0.88±0.12)]and body fat distribution percentage[(36.83±7.63)%vs.(27.12±4.21)%]in the observation group were higher than those in the control group,and adiponectin[(0.68±0.16)mg/L vs.(1.21±0.22)mg/L]was lower than those in the control group,with statistical significance(P<0.05).The total cholesterol,triglycerides,insulin,and insulin resistance index of the observation group were higher than those of the control group(P<0.05).By Pearson analysis,adiponectin was negatively correlated with waist-to-hip ratio,percentage of body fat distribution,total cholesterol,triglyceride,insulin and insulin resistance index(P<0.05).While resistin was positively correlated with waist-to-hip ratio,percentage of body fat distribution,total cholesterol,triglyceride,insulin and insulin resistance index(P<0.05).Waist-to-hip ratio,percentage of body fat distribution,resistin,total cholesterol,triglyceride,insulin and insulin resistance index in the observation group after intervention were all lower than before intervention,and adiponectin was higher than before intervention,with significant differences(P<0.05).Conclusion Compared with normal weight population,adiponectin decreased and resistin and insulin resistance increased in obese population,and adiponectin was negatively correlated with waistto-hip ratio,percentage of body fat distribution,total cholesterol,triglyceride,insulin and insulin resistance index.Resistin was positively correlated with waist-to-hip ratio,percentage of body fat distribution,total cholesterol,triglyceride,insulin and insulin resistance index.Through standardized diet and exercise intervention,lipid levels and insulin resistance of obese people can be improved.