合并血管狭窄左冠状动脉血管瘤的血流动力学仿真与分析

Hemodynamics simulation and analysis of left coronary artery aneurysms with concomitant stenosis

动脉中的血流动力学参数难以无创测量,基于计算流体力学(CFD)对血流动力学参数进行分析与预测已成为生物力学的重要研究热点之一。本文通过建立15种合并狭窄和血管瘤病变的理想化左冠状动脉分叉模型,采用CFD方法对其进行数值仿真,探究了左前降支(LAD)狭窄率和曲率半径对动脉瘤内血流动力学的影响。本研究对不同狭窄率和曲率半径下的模型进行比较,观察发现,随着狭窄率的增加,振荡剪切指数(OSI)和相对滞留时间(RRT)呈现增加趋势;此外,曲率半径的减小导致血管弯曲程度提高,血管瘤破裂的风险增加。其中,当狭窄率小于60%时,狭窄率对动脉瘤破裂的影响更大;当狭窄率大于60%时,曲率半径的影响更为显著。基于本文研究结果可知,综合考虑狭窄率和曲率半径对血流动力学参数的影响,可以对动脉瘤的破裂风险进行分析和预测。本文运用CFD方法深入探究了狭窄率和曲率半径对动脉瘤内血流动力学的影响,为动脉瘤破裂风险的评估提供了新的理论依据和预测手段,具有重要的学术价值和实践指导意义。

The hemodynamic parameters in arteries are difficult to measure non-invasively,and the analysis and prediction of hemodynamic parameters based on computational fluid dynamics(CFD)has become one of the important research hotspots in biomechanics.This article establishes 15 idealized left coronary artery bifurcation models with concomitant stenosis and aneurysm lesions,and uses CFD method to numerically simulate them,exploring the effects of left anterior descending branch(LAD)stenosis rate and curvature radius on the hemodynamics inside the aneurysm.This study compared models with different stenosis rates and curvature radii and found that as the stenosis rate increased,the oscillatory shear index(OSI)and relative residence time(RRT)showed a trend of increase;In addition,the decrease in curvature radius led to an increase in the degree of vascular curvature and an increased risk of vascular aneurysm rupture.Among them,when the stenosis rate was less than 60%,the impact of stenosis rate on aneurysm rupture was greater,and when the stenosis rate was greater than 60%,the impact of curvature radius was more significant.Based on the research results of this article,it can be concluded that by comprehensively considering the effects of stenosis rate and curvature radius on hemodynamic parameters,the risk of aneurysm rupture can be analyzed and predicted.This article uses CFD methods to deeply explore the effects of stenosis rate and curvature radius on the hemodynamics of aneurysms,providing new theoretical basis and prediction methods for the assessment of aneurysm rupture risk,which has important academic value and practical guidance significance.