基于“以补开塞”理论探讨雷火灸干预对非酒精性脂肪肝炎的临床疗效分析

Analysis of the clinical effect of thunder fire moxibustion intervention on non-alcoholic steatohepatitis based on the theory of"through tonifying therapy to relieve blockages"

目的基于“以补开塞”理论探讨雷火灸干预对非酒精性脂肪性肝炎的临床疗效。方法选取2023年1月至8月九江市中医院收治的100例非酒精性脂肪性肝炎患者为研究对象,按照掷硬币法分为对照组(50例)与治疗组(50例),对照组给予非酒精性脂肪性肝炎常规治疗,治疗组在此基础上进行雷火灸干预。比较治疗后两组的临床疗效、体重指数、血脂水平、肝功能指标[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBil)]水平及炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,并进行安全性分析。结果治疗组的总有效率(88.00%)高于对照组(72.00%),差异有统计学意义(P<0.05)。两组患者治疗前的体重指数及血脂水平比较,差异无统计学意义(P>0.05)。两组患者治疗后的体重指数、甘油三酯、总胆固醇水平均低于本组治疗前,差异有统计学意义(P<0.05);且治疗组治疗后的体重指数及甘油三酯、总胆固醇水平均低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的肝功能指标水平比较,差异无统计学意义(P>0.05)。两组患者治疗后的ALT、AST、TBil水平均低于本组治疗前,差异有统计学意义(P<0.05);且治疗组治疗后的ALT、AST、TBil水平均低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的炎症因子水平比较,差异无统计学意义(P>0.05)。两组患者治疗后的IL-6、TNF-α水平均低于本组治疗前,差异有统计学意义(P<0.05);且治疗组治疗后的IL-6、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未发生明显不良反应,治疗后的心电图和三大常规结果均显示正常。结论雷火灸干预非酒精性脂肪性肝炎效果显著,可有效改善患者体重指数、血脂和肝功能,并能明显抑制炎症因子表达,且安全性好,值得推广。

Objective To explore the clinical effect of thunder fire moxibustion intervention on non-alcoholic steatohepatitis based on the theory of"through tonifying therapy to relieve blockages".Methods A total of 100 patients with non-alcoholic steatohepatitis treated in Jiujiang Hospital of Traditional Chinese Medicine from January to August 2023 were selected as the study objects,and they were divided into control group(50 cases)and treatment group(50 cases)according to coin toss method.The control group was given conventional treatment for non-alcoholic steatohepatitis,and the treatment group was given the intervention of thunder fire moxibustion on this basis.The clinical efficacy,body mass index,blood lipid levels,liver function indexes(alanine transaminase[ALT],aspartate transaminase[AST],total bilirubin[TBil])levels and inflammatory factors(interleukin-6[IL-6],tumor necrosis factor-α[TNF-α])levels of the two groups after treatment were compared,and safety analysis was conducted.Results The total effective rate of the treatment group(88.00%)was higher than that of the control group(72.00%),and the difference was statistically significant(P<0.05).There were no statistically significant differences in body mass index and blood lipid levels between the two groups before treatment(P>0.05).The body mass index,triglyceride and total cholesterol levels of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).And the body mass index,triglyceride and total cholesterol levels of the treatment group after treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of liver function indexes between the two groups before treatment(P>0.05).The levels of ALT,AST and TBil in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).And the levels of ALT,AST and TBil in the treatment group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of inflammatory factors between the two groups before treatment(P>0.05).The levels of IL-6 and TNF-α in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).And the levels of IL-6 and TNF-α in the treatment group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no obvious adverse reactions in the two groups during the treatment,and the electrocardiogram and the three routine results were normal after treatment.Conclusion Thunder fire moxibustion has significant effect on the intervention of non-alcoholic steatohepatitis,which can effectively improve the body mass index,blood lipid and liver function of patients,and significantly inhibit the expression of inflammatory factors,and it is safe and worthy of promotion.