炎症性肠病与牙周病的相关性及防治研究进展

Research progress on the correlation between inflammatory bowel disease and periodontal diseases and the prevention and treatment

炎症性肠病和牙周病均为微生物稳态失调与宿主免疫炎症反应相互作用导致的慢性炎症性疾病,二者之间可能通过直接或间接机制相互影响,进而促使另一种疾病发生或加重其原病变程度。直接机制为口腔微生物异位定植于肠道,并激活肠道免疫炎症反应;间接机制包括血液、淋巴循环在内的系统性免疫激活。由于二者存在相似的致病机制,或许可通过研究其共同靶点来探索针对这2种疾病的预防与治疗措施。因此,文章就炎症性肠病与牙周病的相关性及防治研究进展做一综述。

Inflammatory bowel disease and periodontal disease are both chronic inflammatory diseases caused by the interaction between microbial homeostasis imbalance and host immune inflammatory response.The two may interact with each other through direct or indirect mechanisms,thereby promoting the occurrence of another disease or aggravating its original pathological degree.The direct mechanism is the ectopic colonization of oral microbiota in the intestine,which activates the intestinal immune inflammatory response.Indirect mechanisms include systemic immune activation of blood and lymphatic circulation.Due to the similar pathogenic mechanisms between the two,it may be possible to explore prevention and treatment measures for these two diseases by identifying their common targets.Therefore,this article provides a review of the research progress on the correlation between inflammatory bowel disease and periodontal disease as well as the prevention and treatment.