基于两样本孟德尔随机化分析高尿酸与心房颤动的因果关系

The Causal Relationship Between High Uric Acid and Atrial Fibrillation Based on Two-sample Mendelian Randomization

目的:采用两样本孟德尔随机化(Mendelian Randomization,MR)方法,探讨高尿酸与房颤之间的因果关系。方法:从IEU Open GWAS数据库中检索单核苷酸多态性(SNP)数量最多的文献数据,将高尿酸作为暴露因素,将房颤作为结局变量。采用MR-Egger法、逆方差加权法(IVW)进行孟德尔随机化分析,研究高尿酸与房颤的因果关系。结果:去除连锁不平衡影响后,最终确定了3个独立且高度相关的SNPs,的r2值<0.01,与高尿酸水平的关联显著(P值小<5×10^(8))。IVW法估计高尿酸与房颤的因果效应,显示两者存在正向的因果联系(OR=1.745,95%CI为1.012-1.355,P=0.033)。结论:高尿酸与房颤之间存在显著的因果关系,对潜在房颤的高尿酸患者实行早期诊断和干预是必要的。

Objective:Two sample MR was used to investigate the causal relationship between high uric acid and atrial fibrillation.Methods:Literature data with the largest number of SNPS were retrieved from IEU Open GWAS database.High uric acid was used as exposure factor and atrial fibrillation was used as outcome variable.The MR-Egger method and IVW method were used to conduct MR to study the causal relationship between high uric acid and atrial fibrillation.Results:After removing the effects of linkage disequilibrium,three independent and highly correlated SNPs were finally identified with an r²value<0.01,which was significantly associated with high uric acid level(P value<5×10^(8)).IVW method showing a positive causal association(OR=1.745,95%CI 1.012-1.355,P=0.033).Conclusion:There is a significant causal relationship between high uric acid and atrial fibrillation,and it is necessary to implement early diagnosis and intervention for high uric acid patients with potential atrial fibrillation.