乙型肝炎患者白介素-17A血清胆碱酯酶水平与肝功能凝血功能的关系分析

Analysis of the Relationship between Serum Interleukin-17A and Cholinesterase Levels and Liver Function and Coagulation Function in Patients with Hepatitis B

目的探讨乙型肝炎患者白介素-17A、血清胆碱酯酶水平与其肝功能和凝血功能之间的关系。方法选取2023年1月1日—5月31日在光泽县医院诊治的389例乙型肝炎患者作为研究对象,选取同期进行体检的136例健康志愿者作为对照组,根据乙型肝炎患者的病情严重程度分为轻度组126例、中度组130例、重度组133例,评估各组肝功能指标、凝血四项指标、血清胆碱酯酶、白介素-17A水平,分析乙型肝炎患者血清胆碱酯酶、白介素-17A与谷草转氨酶、谷丙转氨酶、凝血四项的关系。结果重度组、中度组、轻度组、对照组的谷草转氨酶、谷丙转氨酶、凝血酶时间、凝血酶原时间、凝血活酶时间、白介素-17A水平逐渐降低,纤维蛋白原和血清胆碱酯酶水平逐渐升高,各组间上述指标差异均存在统计学意义(P<0.05)。血清胆碱酯酶水平与凝血活酶时间、凝血酶原时间、凝血酶时间、谷草转氨酶、谷丙转氨酶水平呈负相关(P<0.05),与纤维蛋白原水平呈正相关(P<0.05);白介素-17A水平与凝血活酶时间、凝血酶原时间、凝血酶时间、谷草转氨酶、谷丙转氨酶水平呈正相关(P<0.05),与纤维蛋白原、血清胆碱酯酶水平呈负相关(P<0.05)。结论乙型肝炎患者血清胆碱酯酶、白介素-17A水平与其凝血功能和肝功能有关,血清胆碱酯酶和白介素-17A水平能够反映患者的病情程度。

Objective To explore the relationship between serum interleukin-17A,serum cholinesterase,liver function,and coagulation function in patients with hepatitis B.Methods A total of 389 hepatitis B patients who were treated at Guangze County Hospital from January 1 to May 31,2023 were selected as study object,as well as 136 cases healthy volunteers who underwent physical examinations during the same period,were selected as the control group.According to the severity of hepatitis B patients,they were divided into mild group(126 cases),moderate group(130 cases),and severe group(133 cases).Liver function indicators,four coagulation indicators,serum cholinesterase,and interleukin-17A levels were evaluated in each group,and the relationship between serum cholinesterase,interleukin-17A,aspartate aminotransferase,and coagulation indicators in hepatitis B patients was analyzed.Results The levels of aspartate aminotransferase,alanine aminotransferase,thrombin time,prothrombin time,thromboplastin time,and interleukin-17A gradually decreased in the severe group,moderate group,mild group,and control group,while the levels of fibrinogen and serum cholinesterase gradually increased.The above index differences between the groups were significant(P<0.05).The serum cholinesterase level is negatively correlated with thrombin time,prothrombin time,thrombin time,aspartate aminotransferase,alanine aminotransferase levels(P<0.05),and positively correlated with fibrinogen levels(P<0.05).The level of interleukin-17A is positively correlated with thrombin time,prothrombin time,thrombin time,aspartate aminotransferase,alanine aminotransferase levels(P<0.05),and negatively correlated with fibrinogen and serum cholinesterase levels(P<0.05).Conclusion The levels of serum cholinesterase and interleukin-17A in patients with hepatitis B are related to their coagulation and liver function.The levels of serum cholinesterase and interleukin-17A can reflect the severity of the patient’s condition.