线粒体衍生肽MOTS-c调节骨稳态机制及运动适应性研究

Research on the Mechanism of Mitochondrial Derived Peptide MOTS-c in the regulation of bone homeostasis and exercise adaptation

骨稳态包括成骨细胞与破骨细胞介导的骨形成与骨吸收,骨组织的完整性依赖二者间的动态平衡。MOTS-c作为一种新型线粒体衍生肽(mitochondria-derived peptides,MDPs)是“线粒体-细胞”间信息交流的重要媒介,在维持机体能量转换和代谢稳态等方面发挥关键作用。研究表明,MOTS-c能调控成骨与破骨细胞活性,从而调节骨代谢平衡。而运动作为外源性刺激,在“细胞-环境”范畴内,通过影响MOTS-c表达参与多种疾病的发展。这表明运动能成为宏观与微观刺激的桥梁,在疾病演变过程中发挥关键作用。然而,罕有文献对MOTS-c调控骨稳态机制进行系统性回顾与总结。此外,运动对骨组织MOTS-c表达调控的详细机制尚不清晰。基于此,本文全面综述了MOTS-c的分布及功能,总结了其影响骨稳态的详细机制,同时对MOTS-c、运动及骨稳态3者间的潜在关联进行了探索性研究,为代谢性骨病的防治提供了新视角。

Bone homeostasis involves bone formation and bone resorption mediated by osteoblasts and osteoclasts,respectively.The integrity of bone tissue is dependent on the dynamic balance between the two.MOTS-c,as a novel mitochondria-derived peptide(MDPs),is an important mediator of mitochondrial-cellular information exchange,and plays an important role in the maintenance of energy conversion and metabolic homeostasis of the body.It plays an important role in the maintenance of energy conversion and metabolic homeostasis.Studies have shown that MOTS-c regulates the activity of osteoblasts and osteoclasts,thus affecting bone homeostasis.Exercise,as an exogenous stimulus,is involved in the development of various diseases by affecting MOTS-c expression in a cell-environment context.This suggests that exercise serves as a bridge between macroscopic and microscopic stimuli and plays an important role in influencing disease development.However,the specific mechanism by which exercise regulates MOTS-c expression in bone tissue is unknown,and the detailed mechanism between MOTS-c and bone homeostasis has rarely been explored.Based on this,this paper comprehensively reviews the distribution and function of MOTS-c,summarizes the detailed mechanisms by which it affects bone homeostasis,and systematically discusses the potential association between MOTS-c,exercise and bone homeostasis,which provides a new perspective for the prevention and treatment of metabolic bone diseases.