miRNA在慢性鼻窦炎伴鼻息肉中的作用及其研究进展

Research progress on the role of miRNA in chronic rhinosinusitis with nasal polyps

慢性鼻窦炎伴鼻息肉(CRSwNP)是耳鼻咽喉科的常见病,其发病机制至今尚不完全清楚,CRSwNP以鼻腔和鼻窦黏膜的高度异质性慢性炎症为特征。炎性改变已被广泛认为是CRSwNP的致病机制。但炎性调控网络复杂,目前尚不清楚哪些关键的上游因子可能参与了CRSwNP的炎性状态。近年研究发现microRNA(miRNA)在CRSwNP的发病过程中起着重要的调控作用,具体可能通过表观遗传等方式参与了这一过程。本文围绕miRNA在CRSwNP中的可能作用,特别聚焦其在炎性环境改变中的潜在作用,包括其表达模式、功能以及潜在的临床应用,归纳了miRNA有关CRSwNP炎症机制及非炎症机制的研究进展,为后续研究提供理论基础。

Chronic rhinosinusitis with nasal polyps(CRSwNP)is a common disease in otorhinolaryngology.The pathogenesis of CRSwNP is still fully unclear.CRSwNP is characterized by highly heterogeneous chronic inflammation of nasal cavity and sinus mucosa.Inflammatory changes have been widely regarded as the pathogenesis of CRSwNP.However,it is complex for the inflammatory regulatory network.Of which contain in their upstream factors,and it is not still understand to be involved in the inflammatory state of CRSwNP.Recent studies have found that microRNA(miRNA)plays an important role in regulating the pathogenesis of CRSwNP.It may be involved in the process of the disease by means of epigenetic inheritance.This paper focuses on the possible role of miRNA in CRSwNP,especially its potential role in inflammatory environment changes,including its expression pattern,function and potential clinical application.We summarized the research progress of miRNA on inflammatory and non-inflammatory mechanisms of CRSwNP,which provided a theoretical basis for further research.