老年体检人群幽门螺杆菌感染与脂质代谢紊乱和甲状腺结节的相关性

Correlation of Helicobacter pylori infection with lipid metabolism disorder and thyroid nodules in elderly population on physical examination

目的研究幽门螺杆菌(Hp)感染与老年体检者脂质代谢紊乱及甲状腺结节的相关性。方法选择2021年3月至2023年8月江南大学附属医院371例体检的老年人群作为样本开展横断面研究,入组后完成Hp感染、脂质代谢和甲状腺结节检查,根据Hp感染情况将患者分为阳性组和阴性组,比较各组血脂水平和甲状腺检查结果。采用Pearson相关系数分析Hp感染与脂质代谢及甲状腺结节间的相关性。采用SPSS 25.0软件进行数据分析。根据数据类型,组间比较分别采用t检验、单因素方差分析及χ2检验。结果371例体检者中Hp感染阳性213例(57.41%)。Hp感染阳性组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平显著升高,高密度脂蛋白胆固醇(HDL-C)水平显著降低,且阳性组高TC血症、高TG血症、高LDL-C血症、低HDL-C血症发生率高于阴性组,差异均有统计学意义(P<0.05);Hp阳性组甲状腺结节检出率显著高于阴性组(P<0.05),两组甲状腺影像报告与数据系统分级比较差异无统计学意义;Hp感染者14 C值与TC、TG和LDL-C水平呈正相关(r=0.398、0.471、0.503;P<0.05),与HDL-C呈负相关(r=-0.426;P<0.05)。结论老年体检人群Hp感染与脂质代谢紊乱和甲状腺结节均具有相关性,且血脂水平与尿素呼气试验检测数值升高的幅度存在密切联系。

Objective To investigate the correlation of Helicobacter pylori(Hp)infection with lipid metabolism disorder and thyroid nodules in the elderly people on physical examination.Methods A cross-sectional study was conducted on 371 elderly population who underwent physical examination in the Affiliated Hospital of Jiangnan University from March 2021 to August 2023.Hp infection,lipid metabolism and thyroid nodules were examined after enrollment.According to Hp infection,the patients were divided into the positive group and the negative group.The blood lipids levels and thyroid examination results were compared between the two groups.Pearson analysis was used to investigate the correlation of Hp infection with lipid metabolism and thyroid nodules.SPSS 25.0 was used for statistical analysis.Data comparison between two groups was performed using t test,one-way analysis of variance,orχ2 test depending on data type.Results Among 371 subjects on physical examination,213(57.41%)were positive for Hp infection.The levels of total cholesterol(TC),triglyceride(TG)and low-density lipoprotein cholesterol(LDL-C)in the positive group were significantly increased,and the level of high-density lipoprotein cholesterol(HDL-C)was significantly decreased;the incidence rates of hyper-TC-emia,hyper-TG-emia,hyper-LDL-C-emia and hypo-HDL-C-emia in the positive group were significantly higher than those in the negative group(P<0.05),and the differences were statistically significant(P<0.05).The detection rate of thyroid nodules was significantly higher in the positive group than that in the negative group(P<0.05),and there was no statistically significant difference in the thyroid imaging reporting and data system gradings between the two groups.The 14 C value of Hp-infected people was positively correlated with the levels of TC,TG and LDL-C(r=0.398,0.471,0.503;P<0.05),and was negatively correlated with HDL-C(r=-0.426;P<0.05).Conclusion Hp infection in the elderly population on physical examination is related to lipid metabolism disorders and thyroid nodules,and there is a close relationship between the levels of blood lipids.