胃肠道肿瘤患者运动干预效果的Meta分析

目的探讨运动在胃肠道肿瘤患者康复治疗中的干预效果。方法通过系统检索中英文数据库(PubMed、Cochrane Library、Web of Science、CNKI和万方数据库),纳入胃肠道肿瘤患者康复运动干预的前瞻性随机对照试验。Revman 5.3系统评估6 min步行试验(6MWT)、行走时间、住院时间、进食时间、疲惫和排便时间、BMI和并发症。结果经过系统检索和文献筛选,17项高质量的随机对照试验研究被纳入定性综合,15项随机对照试验被纳入定量综合。Meta分析结果显示,胃肠道癌症患者的康复训练可有效缩短活动时间(-12.72;95%CI:15.14~-10.30)、住院时间(-0.9;95%CI:-1.55~-0.24)、进食时间(-12.63;95%CI:-14.99~-10.27)、衰竭时间(-9.99;95%CI:11.92~-8.06)和排便时间(-21.25;95%CI:23.52~-18.97),术后并发症减少(0.62;95%CI:0.47~0.82)。6 min步行距离(13.89;95%CI:-25.97~53.68)和BMI(0.57;95%CI:-2.14~3.29)比较无统计学意义(P>0.05)。结论运动干预对胃肠道肿瘤患者的术后恢复具有积极作用。

Objective To explore the intervention effect of exercise in the rehabilitation treatment of gastrointestinal cancer patients.Methods A prospective controlled trial of rehabilitation exercise intervention for gastrointestinal cancer patients was included by systematically searching Chinese and English databases(PubMed,Cochrane Library,Web of Science,CNKI,and Wanfang database).Revman 5.3 system evaluates 6-minute walking test(6MWT),walking time,hospital stay,feeding time,fatigue and defecation time,body mass index(BMI),and complications.Results After systematic retrieval and screening of literature,17 randomized controlled trial(RCT)studies with high quality were included in the qualitative synthesis,and 15 RCT studies were included quantitative synthesis.Meta-analysis results showed that rehabilitation exercise for patients with gastrointestinal cancer could effectively shorten the ambulation time(-12.72,95%CI:-15.14,-10.30),length of hospitalization time(-0.9,95%CI:-1.55,-0.24),eating time(-12.63,95%CI:-14.99,-10.27),time to exhaustion(-9.99,95%CI:-11.92,-8.06)and defecation time(-21.25,95%CI:-23.52,-18.97),and it had a positive effect on reducing postoperative complications(0.62,95%CI:0.47,0.82).However,the six-minute walking distance of rehabilitation exercise for patients with gastrointestinal cancer(13.89,95%CI:-25.97,53.68)and BMI(0.57,95%CI:-2.14,3.29)had no statistical significance(P>0.05).Conclusion Exercise intervention has a positive effect on postoperative recovery of patients with gastrointestinal tumors.