摘要
An efficient visible-light-induced radical cascade azidation/cyclization of 2-aryl indoles with trimethylsilyl azide(TMSN3)has been developed using organic dye Rose Bengal as the photocatalyst.This method did not require metal catalysts and additives,and used air as the oxidant to obtain diverse indolo[2,1-a]isoquinolin-6(5H)-ones in moderate to good yields.Mechanistic studies demonstrated that the reaction proceeded via a radical pathway.
发展了一种以RoseBengal为有机染料光催化剂,在可见光照射下实现2-芳基吲哚与叠氮三甲基硅烷(TMSN3)的自由基叠氮化/环化反应构建叠氮基取代吲哚[2,1-a]异喹啉酮衍生物的方法.该方法无需金属催化剂和添加剂,以空气为氧化剂,以中等到良好的收率得到结构多样的吲哚[2,1-a]异喹啉酮类化合物.机理验证实验表明,该反应经历了自由基历程.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2024年第7期2286-2295,共10页
Chinese Journal of Organic Chemistry
基金
Project supported by the Scientific Research Foundation of Hunan Provincial Education Department(No.23B0650)
the Natural Science Foundation of Hunan Province(No.2022JJ30418)
the Key Scientific Research Foundation of Hunan University of Arts and Science(No.22ZD04)
the Innovation and Entrepreneurship Training Program for College Students of Hunan University of Arts and Science(No.XDC202318)。
