拉贝洛尔联合硫酸镁治疗妊娠高血压的临床效果分析

Analysis of Clinical Effect of Labetalol Combined with Magnesium Sulfate in Treatment of Pregnancy Induced Hypertension

目的:分析拉贝洛尔联合硫酸镁治疗妊娠高血压的临床效果。方法:选择2022年3月—2023年3月东明县妇幼保健院收治的120例妊娠高血压患者作为研究对象,随机分成两组,各60例。对照组使用硫酸镁治疗,观察组在对照组基础上使用拉贝洛尔治疗。比较两组治疗效果。结果:治疗前,两组收缩压、舒张压、平均动脉压对比,无统计学差异(P>0.05);治疗后,两组收缩压、舒张压、平均动脉压降低,且观察组低于对照组(P<0.05)。观察组不良妊娠结局总发生率低于对照组(P<0.05)。观察组不良反应总发生率低于对照组(P<0.05)。治疗后,两组血清白细胞介素(IL-6)水平、24 h尿蛋白定量降低,且观察组低于对照组(P<0.05)。观察组治疗总有效率高于对照组(P<0.05)。结论:拉贝洛尔联合硫酸镁治疗妊娠高血压的临床效果良好,能够控制患者血压,降低IL-6水平、24 h尿蛋白定量,减少不良妊娠结局、不良反应。

Objective:To analyze the clinical effect of labetalol combined with magnesium sulfate in the treatment of pregnancy induced hypertension.Methods:A total of 120 patients with pregnancy induced hypertension admitted to Dongming County Maternal and Child Health Hospital from March 2022 to March 2023 were selected as the study subjects.They were randomly divided into two groups with 60 patients in each group.The control group was treated with magnesium sulfate,and the observation group was treated with labetalol on the basis of control group.The therapeutic effects of the two groups were compared.Results:Before treatment,there was no significant difference in systolic blood pressure,diastolic blood pressure and mean arterial pressure between the two groups(P>0.05).After treatment,systolic blood pressure,diastolic blood pressure and mean arterial pressure decreased in the two groups,and these indicators in the observation group were lower than those in the control group(P<0.05).The total incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).After treatment,the serum interleukin(IL-6)level and 24-hour urine protein quantification decreased in the two groups,and these indicators in the observation group were lower than those in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).Conclusion:Labetalol combined with magnesium sulfate has good clinical effect in the treatment of pregnancy induced hypertension,and can control blood pressure,reduce IL-6 level and 24-hour urine protein quantification,and reduce adverse pregnancy outcomes and adverse reactions.