从病因病机共性探讨2型糖尿病、非酒精性脂肪性肝病与高尿酸血症内在联系

Exploration on the Internal Relationship among Type 2 Diabetes Mellitus,Nonalcoholic Fatty Liver Disease,and Hyperuricemia

2型糖尿病、非酒精性脂肪性肝病与高尿酸血症的发生存在一定相关性。三者发生发展过程中均存在胰岛素抵抗、氧化应激及肠道屏障损伤,有相似的生理病理基础。中医学认为,三者“共病”是以浊毒困脾为病机,存在湿、痰、浊、毒、瘀等证候要素,治疗以健脾化浊解毒为总则,故3种疾病在中医病因病机及治疗上有相似之处。本文基于“异病同治”理论探讨2型糖尿病、非酒精性脂肪性肝病与高尿酸血症内在相关性,以期在临床中实现早预防、早诊断、早治疗。

There is certain correlation among type 2 diabetes mellitus(T2DM),nonalcoholic fatty liver disease(NAFLD),and hyperuricemia(HUA).Insulin resistance,oxidative stress,and damage to the intestinal barrier are present in the development of all three ailments.These three conditions share a similar physiological and pathological basis.In TCM,the co-morbidity of T2DM,NAFLD and HUA is explained through the pathogenesis of turbid toxicity trapping spleen.There are syndromes of dampness,phlegm,turbidity,toxicity,and blood stasis as contributing elements.The general rule for treatment involves strengthening the spleen to resolve turbidity and detoxify.Therefore,there are similarities in the etiology,pathogenesis,and treatment of these three diseases in TCM.This article is based on the theory of“treating different diseases with the same treatment”explores the internal correlation between T2DM,NAFLD and HUA,in order to achieve early prevention,early diagnosis and early treatment in clinical practice.