基于CiteSpace及VOSviewer中药毒理学研究文献可视化分析

Visualization Analysis on Research Literature about TCM Toxicology Based on CiteSpace and VOSviewer

目的通过对国内中药毒理学领域相关文献进行可视化分析,了解其研究历程、现状及热点前沿、发展趋势,为中药毒理学研究提供参考。方法检索中国学术期刊网络版(CAJD)、万方医学网、中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)中药毒理学相关文献,检索时限自建库至2023年4月15日,采用NoteExpress3.7.0软件去重及人工筛选,利用Excel2003软件分析纳入文献发文时间,利用VOSviewer1.6.18软件对纳入文献发文期刊、机构、作者进行可视化分析,利用CiteSpace6.2.R5进行关键词共现、聚类、时间线及突现分析。结果共纳入文献2086篇,发文量整体呈上升趋势。共涉及期刊641本、研究机构1702个、作者6270位,其中核心作者245位,形成了以孙蓉、高月、彭成、黄芳华、苗明三为代表的研究团队。研究机构以中国中医科学院、国家药品监督管理局、北京中医药大学、南京中医药大学、广州中医药大学为主。共纳入521个关键词,频次及中介中心性较高的关键词有中药、不良反应、毒理学、急性毒性、大鼠、临床应用;形成了说明书、毒理学、临床应用等16个关键词聚类;突现关键词有17个,肝毒性、作用机制、分子对接为目前研究热点。结论中药毒理学研究逐年增多,发展前景良好,但需加强研究团队间跨地域合作,近年研究热点集中在肝毒性、作用机制、分子对接方面,智能预测评估中药毒性、防控临床应用风险可能为未来研究趋势。

Objective To understand the research history,current status and hot frontiers,development trend of TCM toxicology by visualizing and analyzing the relevant literature in the field of TCM toxicology in China;To provide reference for the research of TCM toxicology.Methods The literature related to TCM toxicology was retrieved from CAJD,Wanfang Med Online,VIP,and SinoMed from the establishment of the databases to April 15,2023,and NoteExpress 3.7.0 was used to perform the literature de-emphasis and manual screening.Excel 2003 was used to analyze publication time of included literature.CiteSpace 6.2.R5 was used to conduct keyword co-occurrence,clustering,timeline,and emergent analysis.Results A total of 2086 articles were included,with an overall increasing trend in the number of publications.A total of 641 journals,1702 research institutions,and 6270 authors were involved,including 245 core authors,forming research teams represented by Sun Rong,Gao Yue,Peng Cheng,Huang Fanghua,and Miao Mingsan.The research institutions were concentrated in China Academy of Chinese Medical Sciences,National Medical Products Administration,Beijing University of Chinese Medicine,Nanjing University of Chinese Medicine,and Guangzhou University of Chinese Medicine.A total of 521 keywords were included,and the keywords with higher frequency and intermediary centrality were Chinese materia medica,adverse reaction,toxicology,acute toxicity,rat,and clinical application;16 keyword clusters such as instruction manuals,toxicology,and clinical application were formed;there were 17 emergent keywords,and hepatotoxicity,mechanism,and molecular docking were the main hotspots of the current research.Conclusion The research in the field of TCM toxicology has been increasing year by year,and its development prospects are promising,and it is still necessary to strengthen the cooperation between different research teams and organizations.In recent years,the research hotspots focus on hepatotoxicity,mechanism,molecular docking,etc.Intelligent prediction and assessment of TCM toxicity,and the prevention and control of the risk of clinical application are the possible research trends in the future.