关于少弱畸形精子症蛋白组学的研究进展

Proteomics of Oligoasthenoteratozoospermia:Progress in research

少弱畸形精子症(OAT)是导致男性不育的常见疾病,特征为精子数量减少及活力降低。该疾病的发病机制复杂,涉及生活方式、遗传异常、环境因素等。近年来,精子蛋白组学的研究取得显著进展,尤其是在OAT患者中的应用。本文综述了OAT患者精子及精浆蛋白组的研究进展,描述了与精子活力和数量相关的潜在差异蛋白,旨在深入理解OAT的病理机制,提高诊断准确性,并探索新的生物标记物。

Oligoasthenoteratozoospermia(OAT) is a common male infertility condition characterized by a decreased sperm count and poor sperm motility.The pathogenesis of OAT is rather complicated,involving such factors as lifestyle,genetic abnormalities,environmental pollutants,and others.In recent years,significant progress has been made in the study of sperm proteomics,particularly in its application to the diagnosis and treatment of OAT.This review summarizes the advances in the proteomic studies of sperm and seminal plasma in OAT patients,provides an overview of the potential differentially expressed proteins associated with sperm count and motility,aiming for a deeper insight into the pathogenesis of OAT and improvement of its diagnosis and identification of its related new biomarkers.