肝细胞癌进展过程中KLFs异常表达及其检测的临床价值研究进展

Abnormal expressions of Krüppel-like factors in progression of hepatocellular carcinoma

肝细胞癌(HCC)发生机制尚未完全阐明,肝细胞恶性转化的监测极其重要。新近发现在HCC进展过程中,人类最大的锌指蛋白转录因子家族的Krüppel样因子(KLFs)发挥重要的促进或抑制作用。基础和临床研究显示部分KLFs有望成为诊断和预测HCC预后的分子标志物,并有望成为基因治疗的分子靶标。本文综述了肝癌相关KLFs的组织分布,表达特征及其临床应用价值。

The mechanisms of hepatocarcinogenesis have not been fully elucidated.Krüppel-like factors(KLFs),the largest family of zinc finger protein(ZFP)transcription factors in humans,have recently been found to play a promoting or inhibiting role in hepatocellular carcinoma(HCC)progression.Basic and clinical studies have shown that part of KLFs might be used as molecular markers for diagnosis and for predicting prognosis of patients with HCC.It is also possible as a molecular targets for gene therapy.This article reviews the tissue distribution,expressing features and clinical application of HCC-related KLFs.