肿瘤坏死因子相关凋亡诱导配体基因多态性与糖尿病型牙周炎易感性的关系探讨

Association of tumor necrosis factor related apoptosis inducing ligand(TRAIL)gene polymorphism with susceptibility to diabetes periodontitis

目的:探讨肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor-associated apoptosis-inducing ligand,TRAIL基因多态性与糖尿病型牙周炎易感性的相关性。方法:选择2022年9月—2023年9月收治的150例2型糖尿病患者作为研究对象,根据患者是否合并牙周炎分为合并组(n=50)、非合并组(n=50)和对照组(n=50)。收集患者临床病历资料,检测TRAIL G1525A与C1595T基因多态性,分析2型糖尿病型牙周炎的影响因素。采用SPSS 19.0软件包对数据进行统计学分析。结果:合并组和非合并组空腹血糖(FBG)、附着丧失(AL)、龈沟出血指数(SBI)和血钙显著低于对照组,糖化血红蛋白(HbA1c)和血清碱性磷酸酶(ALP)显著高于对照组(P<0.05)。合并组TRAIL G1525A基因中GG基因频率显著高于非合并组和对照组(P<0.05)。3组TRAIL C1595T各基因型分布相比,差异无统计学意义(P>0.05)。HbA1c、AL、SBI、ALP和TRAIL G1525A多态性是牙周炎的危险因素(P<0.05)。TRAIL G1525ALeuGG位点在中重度与轻度牙周炎患者中的分布相比,差异有统计学意义(P<0.05)。结论:TRAIL G1525A基因与糖尿病型牙周炎的易感性相关,GG基因型的2型糖尿病患者患牙周炎风险较高。

PURPOSE:To explore the association between tumor necrosis factor-associated apoptosis-inducing ligand(TRAIL)gene polymorphism and susceptibility to diabetic periodontitis.METHODS:A total of 150 patients with type 2 diabetes were selected from September 2022 to September 2023.The patients were divided into combined group(n=50),non-combined group(n=50)and control group(n=50)according to whether they had periodontitis.Clinical medical records of all subjects were collected,TRAIL G1525A and C1595T gene polymorphisms were detected,and the influencing factors of type 2 diabetic periodontitis were analyzed.Statistical analysis was performed with SPSS 19.0 software package.RESULTS:In combined and non-combined group,the fasting blood glucose(FBG),loss of attachment(AL),gingival crevicular bleeding index(SBI)and blood calcium were significantly lower than those in the control group,and HbA1c and serum alkaline phosphatase(ALP)were significantly higher than those in the control group(P<0.05).The GG gene frequency of TRAIL G1525A gene in the combined group was significantly higher than that in the non-combined group and control group(P<0.05).There was no significant difference in genotype distribution of TRAIL C1595T among three groups(P>0.05).HbA1c,AL,SBI,ALP and TRAIL G1525A polymorphisms were risk factors for periodontitis(P<0.05).The distribution of TRAIL G1525ALeuGGin with moderate and severe periodontitis was significantly different from that with mild periodontitis(P<0.05).CONCLUSIONS:TRAIL G1525A gene is associated with the susceptibility of diabetic periodontitis,and GG genotype patients with type 2 diabetes have a higher risk of periodontitis.