外泌体在特发性肺纤维化中的诊疗研究进展

Progress on the diagnosis and treatment of Exosomes in Idiopathic Pulmonary Fibrosis

特发性肺纤维化(IPF)是一种病因不明的慢性间质性肺病,患者生存期短,预后不良,且难以完全治愈。目前IPF的主要诊断方法为高分辨率CT(HRCT),它的缺陷是受评判者主观影响大,重复性不高。因此,为了辅助IPF的诊断及预后,有必要研发新的生物标志物。近年来越来越多的研究集中在外泌体(Exos),尽管它在恶性肿瘤和心血管疾病等领域的研究已经十分深入,但其对IPF的具体调控机制尚未完全阐明。此外,外泌体可由不同细胞和不同体液分泌,且在提示IPF风险和诊断预后方面都具有潜在的应用价值。

Idiopathic Pulmonary Fibrosis is a chronic interstitial lung disease of unknown etiology with a short survival period,poor prognosis,and difficult to completely cure.At present,the main diagnostic method of IPF is High Resolution CT(HRCT),which has the disadvantage of high subjective impact and low repeatability.Therefore,it is necessary to develop novel biomarkers to aid in the diagnosis and prognosis of IPF.In recent years,more and more studies have focused on exosomes,whose specific regulatory mechanisms for IPF have not been fully elucidated,although it has been extensively studied in the field of malignant tamors and cardiovascular disease.In addition,exosomes can be secreted by different cells and body fluids,having potential applications in suggesting IPF risk and diagnostic prognosis.