基于训练免疫疫苗的研究进展

Current progress on trained immunity-based vaccines

基于训练免疫的疫苗(TIbV)是疫苗研究领域的一种新兴策略,它是指基于训练免疫(TI)原理设计的疫苗。TI是指天然免疫细胞经过驯化后能在再次刺激后产生增强的免疫反应。TIbV通过训练宿主天然免疫系统获得天然免疫记忆,来增强对多种感染病原体的抵抗力,其中包括除被疫苗所覆盖的特定病原体之外的其他病原体。本文将综述TIbV概念、机制、应用领域以及未来前景,以期为疫苗研发设计提供一种参考。

Trained immunity-based vaccines(TIbV)is an emerging vaccine strategy in the field of vaccine research,referring to vaccines designed based on the principles of trained immunity(TI).TI involves the enhanced immune response of innate immune cells upon re-stimulation after being trained.TIbV,built on the concept of TI,aims to enhance resistance to various infectious pathogens by training the host′s innate immune system to acquire natural immune memory.This approach is designed to bolster immunity against a wide range of infectious agents,including those not covered by conventional vaccines.This article reviews the concepts,mechanisms,application areas,and future prospects of TIbV,intending to offer a new perspective for vaccine development and design.