中西医结合视域下肿瘤转移态学说的初步构建

Initial Construction of the Tumor Metastatic State Doctrine under the Perspective of Integration of Chinese and Western Medicine

基于中医学“以人为本”和现代医学“抑瘤为主”的理念,梳理中医、西医不同角度对肿瘤转移时空演变规律及生物学特征的研究,从肿瘤细胞与机体免疫动态博弈的角度初步提出中西医结合视域下的肿瘤转移态学说,即转移的形成是体内癌细胞与其周围环境因素随时间-空间动态演变的结果。认为转移态的症状表现具有系统性、转移态的诱发因素具有恒动性、转移态临床结局具有阶段性,据此提出从时空动态变化角度认识转移发生的机制,建立标识转移态的临床与病理模型,揭示转移发生的临界点,从而促进肿瘤转移研究从静态向动态转变,为制定转移防治策略、构建临床肿瘤转移防治新体系提供思路。

Based on the concepts of"people-oriented"in traditional Chinese medicine and"tumor-suppression"in modern medicine,we have combed the studies on the spatial and temporal evolution of tumor metastasis and its bio⁃logical characteristics in different perspectives,and initially proposed the theory of tumor metastasis from the per⁃spective of the dynamic game between the tumor cells and the body's immune system under the theory of the integra⁃tion of Chinese and Western medicine,that is,the formation of metastasis is the result of the dynamic evolution of the cancer cells and their surrounding environmental factors in the body over time and space.It is believed that the symp⁃tomatic manifestation of metastasis is systematic,the triggering factors of metastasis are constant,and the clinical out⁃come of metastasis is staged.Accordingly,it is proposed to understand the mechanism of metastasis from the perspec⁃tive of spatial and temporal dynamics,to establish a clinical and pathological model for identifying metastasis,and to reveal the critical point of metastasis,so as to facilitate the change of the research on tumor metastasis from static to dynamic,and provide ideas for the formulation of metastasis prevention and treatment strategies,and the construction of a new system of metastasis prevention and treatment in the clinical tumor field.