FLASH放疗相关临床试验研究进展

Research advances in FLASH radiotherapy-related clinical trials

近年来,FLASH放疗受到国际放疗学界的关注。与常规放疗相比,FLASH放疗能够在极短时间内将全部照射剂量注入靶区,在保持相同抗肿瘤效果的前提下减轻正常组织的放射损伤。目前,FLASH放疗已处于临床试验阶段,一些临床研究成果陆续被报道。本文通过整理近年来FLASH放疗的全球临床研究成果,对其在肿瘤临床试验中的安全性、放射相关不良反应、治疗效果及面临的机遇与挑战等方面进行系统综述。

FLASH radiotherapy(FLASH-RT)has garnered considerable attention globally in recent years.Compared to conventional radiotherapy,FLASH-RT can deliver the total radiation dose to the target volume in an extremely short time,reducing the radiation-induced damage to normal tissue while maintaining similar anti-tumor effects.FLASH-RT has been in the clinical trial stage,with several clinical research result being reported.Based on the collected global clinical research result of FLASH-RT in recent years,this study systematically reviewed FLASH-RT's safety,radiation-related side effects,treatment efficacy,opportunities,and challenges in clinical trials.