维生素D联合家庭干预治疗儿童孤独症谱系障碍的疗效观察

Observation on the curative effect of vitamin D combined with family intervention in the treatment of children with autism spectrum disorder

目的:探讨维生素D联合家庭干预治疗儿童孤独症谱系障碍(ASD)的效果。方法:本研究纳入2021年1月—2023年3月江西省妇幼保健院儿保科收治的ASD患儿,依家长意愿分为两组。对照组进行家庭干预,观察组进行维生素D联合家庭干预。使用孤独症行为量表(ABC)与卡式量表(CARS)评估治疗前及治疗3个月后症状变化,并通过荧光免疫层析法检测25羟基维生素D[25(OH)D]水平,以探讨不同干预措施对ASD儿童症状及维生素D营养状况的影响。结果:两组患儿治疗3个月后的ABC总分、CARS总分较治疗前降低,且观察组患儿ABC总分、CARS总分低于对照组(P<0.05)。观察组患儿治疗3个月后末梢血25(OH)D水平较治疗前升高(P<0.05)。结论:与单独进行家庭干预相比,维生素D联合家庭干预对改善ASD患儿核心症状的效果更优。

Objective To explore the effect of vitamin D combined with family intervention in the treatment of children with autism spectrum disorder(ASD).Method In this study,children with ASD admitted to the Child Healthcare Department of Jiangxi Maternal and Child Health Hospital from January 2021 to March 2023 were included and divided into two groups according to their parents'wishes.The control group received family intervention,and the observation group received vitamin D combined with family intervention.The Autism Behavior Scale(ABC)and Childhood Autism Rating Scale(CARS)were used to evaluate the changes of symptoms before and 3 months after treatment,and the 25 hydroxyvitamin D[25(OH)D]levels were detected by fluorescence immunochromatography to explore the effects of different interventions on symptoms and vitamin D nutritional status of children with ASD.Result After 3 months of treatment,the total scores of ABC and CARS in the two groups were lower than before treatment,and the total scores of ABC and CARS in the observation group were lower than those in the control group(P<0.05).The levels of peripheral blood 25(OH)D in the observation group after 3 months of treatment were higher than those before treatment(P<0.05).Conclusion Compared with family intervention alone,vitamin D combined with family intervention has a better effect on improving the core symptoms of children with ASD.