2022年5—6月上海市浦东新区新型冠状病毒感染出院病例复阳流行病学特征

Epidemiological characteristics of recovered COVID-19 cases with re-positive nucleic acid in Pudong New Area of Shanghai from May to June 2022

【目的】了解上海市浦东新区新型冠状病毒感染(COVID-19)病例出院后复阳的流行病学特征,为疫情防控提供参考。【方法】对2022年5月20日—6月20日上海市浦东新区治愈出院的339例COVID-19病例进行3个月的健康随访和核酸检测,分析其流行病学特征。【结果】339例随访病例中复阳病例75例,复阳率为22.12%。不同性别、不同年龄组、不同职业、是否有心脏病、是否有高血压、是否全程接种疫苗对病例复阳均无影响。病例在首次感染时被诊断为确诊病例、患有糖尿病、住院时间≤7 d为复阳的相关因素。出院至复阳时间间隔中位数为26 d。复阳病例的密接在隔离观察期结束后均未感染新型冠状病毒。【结论】COVID-19病例治愈出院后存在复阳情况,首诊为确诊病例及住院时间7 d以内的病例复阳率较高,未发现复阳病例引起续发传播。

[Objective]To understand the epidemiological characteristics of recovered COVID-19 cases with re-positive nucleic acid in Pudong New Area of Shanghai,and to provide a reference for the prevention and control of COVID-19.[Methods]A three-month health follow-up and nucleic acid testing were conducted on 339 COVID-19 cases cured and discharged between May 20 and June 20,2022,in Pudong New Area,Shanghai,to analyze their epidemiological characteristics.[Results]Among the 339 follow-up cases,75 cases experienced re-positive nucleic acid results,with a recurrence rate of 22.12%.Factors such as gender,age group,occupation,presence of heart disease,hypertension,and full vaccination status had no effect on the re-positive results.Being diagnosed as a confirmed case during the first presence of infection,having diabetes,and a hospitalization period of≤7 days were related factors for recurrence.The median interval between discharge and re-positive nucleic acid results was 26 days.The close contacts of the re-positive cases did not contract COVID-19 after the isolation and observation period.[Conclusion]There is a possibility of re-positive nucleic acid results after COVID-19 recovery and discharge.Cases initially diagnosed as confirmed cases and those with a hospitalization period of no more than 7 days have a high rate of re-positivity.No secondary transmission is observed from the re-positive cases.