老年2型糖尿病患者肌少症与血糖目标范围内时间的相关性研究

Correlation between Sarcopenia and Time within the Target Range of Blood Glucose in Elderly Patients with T2DM

目的:探讨老年2型糖尿病患者肌少症与血糖目标范围内时间(TIR)的相关性。方法:选择2022年6月—2023年6月上海市杨浦区控江医院收治的102例老年2型糖尿病患者,根据肌力水平的不同将其划分为肌少症组(n=22)和非肌少症组(n=80)。比较两组患者空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、四肢骨骼肌质量指数(ASMI)、TIR、血糖低于目标范围内时间(TBR)、血糖高于目标范围内时间(TAR)水平,采用Pearson相关分析法分析ASMI、握力与TIR、TBR、TAR的相关性。结果:肌少症组患者的空腹血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均高于非肌少症组,高密度脂蛋白胆固醇水平低于非肌少症组,差异有统计学意义(t值分别为5.395、2.003、2.479、3.819、2.568,P<0.05);肌少症组患者的TIR水平低于非肌少症组,TBR、TAR水平均高于非肌少症组,差异有统计学意义(t值分别为9.163、17.553、18.604,P<0.05);Pearson相关分析结果显示,老年2型糖尿病患者ASMI、握力与TIR均呈正相关,ASMI、握力与TBR、TAR均呈负相关。结论:老年2型糖尿病患者肌少症与TIR、TBR、TAR水平密切相关,监测TIR、TBR、TAR指标的水平变化对老年2型糖尿病患者肌少症病情的评估及临床治疗具有重要意义。

OBJECTIVE To investigate the correlation between sarcopenia and time within the target range of blood glucose in elderly patients with type 2 diabetes mellitus(T2DM).METHODS 102 elderly T2DM patients admitted to Kongjiang Hospital of Shanghai Yangpu District from June 2022 to June 2023 were selected as the research subjects.Based on different muscle strength levels,the 102 patients were divided into a sarcopenia group of 22 cases and a non sarcopenia group of 80 cases.Compare two groups of glucose and lipid metabolism indicators[fasting blood glucose(FBG),total cholesterol(TC),triglycerides(TG),low-density lipoprotein(LDL-C),high-density lipoprotein cholesterol(HDL-C)],limb skeletal muscle mass index(ASMI),grip strength,time within target blood glucose range(TIR),time below target blood glucose range(TBR),and time above target blood glucose range(TAR)levels.Pearson correlation analysis to analyze ASMI The correlation between grip strength and TIR,TBR,TAR.RESULTS The levels of FBG,TC,TG,and LDL-C in the sarcopenia group were higher than those in the non sarcopenia group,while the levels of HDL-C were lower than those in the non sarcopenia group,the difference were statistically significant(t=5.395,2.003,2.479,3.819,2.568,P<0.05).The TIR levels of patients with sarcopenia were lower than those in the non sarcopenia group,while the TBR and TAR levels were higher than those in the non sarcopenia group,the difference were statistically significant(t=9.163,17.553,18.604,P<0.05).Pearson correlation analysis showed that ASMI and grip strength were positively correlated with TIR,while ASMI and grip strength were negatively correlated with TBR and TAR in elderly T2DM patients.CONCLUSION The sarcopenia in elderly T2DM patients is closely related to the levels of TIR,TBR and TAR,monitoring the changes of TIR,TBR and TAR indexes is of great significance for evaluating the condition and clinical treatment of sarcopenia in elderly T2DM patients.