天然植物多酚化合物的共组装策略研究综述

Co-assembly Strategy Study Review of Natural Plant Polyphenolic Compounds

多酚是植物无处不在的次生代谢产物,是人类和动物饮食中不可或缺的一部分,并且植物多酚能够调节人体多种生理途径,对高血压、过敏、癌症、衰老以及心脏病等方面有非常显著的作用,引起了生物医学的极大关注。然而,多酚有着较差的溶解度和快速的代谢消耗,并在光、热和pH值变化时生物活性不稳定,这影响了其在机体内的生物利用率,限制了其生理活性的发挥。目前,各种研究工作都在探索提高多酚化合物利用率的方法,如金属配位和氧化偶联/聚合,但是这些方法都离不开基本的多酚共组装驱动力来促进多酚与多种材料的结合。本综述旨在介绍天然植物多酚化合物的共组装策略,主要包括天然植物多酚化合物分类的概述以及共组装驱动力介绍。

Polyphenols,ubiquitous secondary metabolites of plants,are an integral part of the human and animal diets.Meanwhile,plant polyphenols can regulate a variety of physiological pathways in the human body,with highly significant effects on hypertension,allergies,cancer,aging,and heart disease,which have attracted significant biomedical attention.However,polyphenols have poor solubility and rapid metabolic consumption,and their bioactivity is unstable under light,heat and pH changes,which affects their bioavailability in the organism and limits their physiological activity.Currently,various research efforts are exploring methods to enhance the utilization of polyphenolic compounds,such as metal coordination and oxidative coupling/polymerization.However,none of these approaches can be separated from the basic polyphenol co-assembly drivers to facilitate the binding of polyphenols to a wide range of materials.This review aims to present co-assembly strategies for natural plant polyphenolic compounds,including an overview of the classification of natural plant polyphenolic compounds and an introduction to co-assembly drivers.