孟德尔随机化在类风湿关节炎相关研究中的应用

Application of Mendelian randomization in rheumatoid arthritis-related research

近年来,基于全基因组关联研究的孟德尔随机化(MR)研究方法被广泛应用于医学领域的病因探索,以其遗传变异的分配随机性和时序优先性的独特优势,可以有效克服传统观察性研究中的混杂偏倚和反向因果干扰。类风湿关节炎(RA)是多个小关节累及的自身免疫性疾病。由于免疫机制复杂,RA的病因尚未得到系统阐明。现对MR研究方法及其在RA与肠道菌群、药物、特定疾病、生活方式、炎症标志物等相关研究中的应用进行综述,以期为RA因果关联研究方面提供新思路。

In recent years,the Mendelian randomization(MR)research method,based on genome-wide association studies,has been widely applied in the field of medicine for etiological exploration.With its unique advantages of random allocation of genetic variations and temporal priority,it can effectively overcome the confounding biases and reverse causal interference in traditional observational studies.Rheumatoid arthritis(RA)is an autoimmune disease involving multiple small joints.Due to the complexity of immune mechanisms,the etiology of RA has not been systematically elucidated.This article reviews the MR research method and its application in the study of RA and intestinal flora,medications,specific diseases,lifestyle and inflammatory markers,in order to provide new ideas for the study of causal associations in RA.