超声靶向微泡破坏技术在肝细胞癌基因治疗中的应用研究进展

Research progress on the application of ultrasound-targeted microbubble destruction technology in gene therapy for hepatocellular carcinoma

肝细胞癌(HCC)是常见的恶性肿瘤之一,基因治疗作为一种新型治疗手段,已经在HCC治疗中展现出巨大的潜力。近年来,超声靶向微泡破坏(UTMD)技术作为一种新型的基因递送技术,在HCC基因治疗中取得了一些重要的研究进展,从UTMD介导自杀基因、基因沉默、增加基因表达以及联合其他载体治疗等方面进行了深入研究,进而为HCC的诊断和治疗提供可靠的方法。因此,现对UTMD技术在HCC基因治疗中的应用进行综述。

Hepatocellular carcinoma(HCC)is one of the common malignant tumors,and gene therapy,as a novel therapeutic tool,has shown great potential in the treatment of HCC.In recent years,ultrasound-targeted microbubble disruption(UTMD)technology,as a novel gene delivery technology,has made some important research progress in HCC gene therapy,which has been studied in depth from various aspects,such as UTMD-mediated suicide genes,gene silencing,increase of gene expression,and combined with other vector therapies,which in turn provides a reliable method for the diagnosis and treatment of HCC.Therefore,this review summarizes the application of UTMD technology in HCC gene therapy.