心血管衰老机制:巨自噬功能受损和表观遗传学改变

Mechanism of cardiovascular aging: impaired macroautophagy function and epigenetic changes

心血管系统在持续的机械和代谢压力下运行,随着年龄的增长,在分子、细胞和器官水平上发生功能障碍的风险逐渐升高。特别是巨自噬功能受损和表观遗传学改变,其中包括DNA甲基化、组蛋白修饰和非编码RNA。这些心血管衰老机制紧密交织,个别机制的加强或减弱会影响其他机制。了解心血管衰老机制,有望为今后心血管疾病的诊断及新药研发提供新的思路和方向。

The cardiovascular system operates under continuous mechanical and metabolic pressure,and as age increases,the risk of functional impairment at the molecular,cellular,and organ levels gradually increases.Especially with impaired macroautophagy function and epigenetic changes,including DNA methylation,histone modifications,and non-coding RNA.These cardiovascular aging mechanisms are closely intertwined,and the strengthening or weakening of individual mechanisms can affect other mechanisms.Understanding these cardiovascular aging mechanisms is expected to provide new ideas and directions for the diagnosis of cardiovascular diseases and the development of new drugs in the future.