麝香活血化瘀膏治疗膝骨关节炎的临床效果观察

Observation on clinical effect of muscovite-infused blood circulation and blood stasis ointment on knee osteoarthritis

目的 评价麝香活血化瘀膏治疗膝骨关节炎(knee osteoarthritis,KOA)的效果及安全性。方法 选取2020年9月至2022年12月于全国11个医院骨伤科门诊就诊的KOA患者1 600例,按3∶1比例将其随机分为研究组(n=1 200,麝香活血化瘀膏治疗)和对照组(n=400,双氯芬酸二乙胺乳胶剂治疗),两组疗程均为14 d。比较两组西安大略和麦克马斯特大学骨关节炎指数(Western Ontario and McMaster universities arthritis index,WOMAC)评分、视觉模拟疼痛评分(visual analogue scale,VAS)、中医证候积分量表及膝关节肿胀量表评分等,并观察不良反应发生情况。结果 研究组治疗总有效率高于对照组(86.75% vs 76.50%,P<0.05)。两组WOMAC评分、VAS、中医证候积分量表及膝关节肿胀量表评分较前均明显改善,且研究组中医证候积分量表及膝关节肿胀量表评分改善程度优于对照组(P<0.05)。治疗期间,两组均未出现药物中毒或肝肾功能损伤等不良反应。结论 麝香活血化瘀膏能有效改善KOA患者临床症状,效果确切且安全性高。

Objective To evaluate the efficacy and safety of muscovite-infused blood circulation and blood stasis ointment in the treatment of knee osteoarthritis(KOA).Methods A total of 1600 KOA patients treated in orthopedics and traumatology departments of 11 hospitals across the country from September 2020 to December 2022 were selected and randomly divided into experimental group(n=1200,treated with muscovite-infused blood circulation and blood stasis ointment)and control group(n=400,treated with diclofenac diethylamine emulgel)according to a ratio of 3∶1.The course of treatment in both groups was 14 days.Western Ontario and McMaster universities arthritis index(WOMAC)score,visual analogue scale(VAS),traditional Chinese medicine(TCM)syndrome score scale and knee swelling scale score,etc.,and the occurrence of adverse reactions were observed in both groups.Results The total effective rate of the experimental group was higher than that of the control group(86.75%vs 76.50%,P<0.05).The scores of WOMAC,VAS,TCM syndrome score scale and knee swelling scale in both groups were significantly improved,and the improvement of TCM syndrome score scale and knee swelling scale in the experimental group were better than those in the control group(P<0.05).During the treatment period,there were no adverse reactions such as drug poisoning or liver and kidney function injury in both groups.Conclusion Muscovite-infused blood circulation and blood stasis ointment can effectively improve the clinical symptoms of KOA patients,with accurate effect and high safety.