Myc诱导的核抗原53在胆囊癌组织中的表达及临床意义

Expression and clinical significance of Myc induced nuclear antigen 53 in gallbladder cancer tissues

目的探讨Myc诱导的核抗原53(Mina53)在胆囊癌组织中的表达及临床意义。方法采用免疫组化法检测62例胆囊癌手术患者胆囊癌组织及癌旁组织中Mina53的表达情况,比较胆囊癌组织和癌旁组织以及不同临床特征胆囊癌患者胆囊癌组织中Mina53的表达情况。结果62例胆囊癌组织中,Mina53阳性49例,阴性13例;62例癌旁组织中,Mina53阳性2例,阴性60例。Mina53在胆囊癌组织中的阳性表达率为79.03%,高于癌旁组织的3.23%,差异有统计学意义(P﹤0.05)。不同浸润深度、淋巴结转移情况、肝脏转移情况、分化程度、TNM分期、神经侵犯情况、脉管侵犯情况胆囊癌患者胆囊癌组织中Mina53的阳性表达率比较,差异均有统计学意义(P﹤0.05)。结论Mina53在胆囊癌组织中呈特异性高表达,并且其表达情况与浸润深度、分化程度、淋巴结转移情况、肝脏转移情况、TNM分期、神经侵犯情况、脉管侵犯情况有关。

Objective To investigate the expression and clinical significance of Myc induced nuclear antigen 53(Mina53)in gallbladder cancer tissues.Method The expression of Mina53 in gallbladder cancer tissues and paracancer tissues of 62 patients with gallbladder cancer who underwent surgery were detected by immunohistochemical method.The expression of Mina53 in gallbladder cancer tissues and paracancer tissues as well as in gallbladder cancer tissues of gallbladder cancer patients with different clinical features were compared.Result Among 62 cases of gallbladder cancer tissues,Mina53 was positive in 49 cases and negative in 13 cases.Among 62 cases of paracancer tissues,Mina53 was positive in 2 cases and negative in 60 cases.The positive expression rate of Mina53 in gallbladder cancer tissues was 79.03%,which was higher than 3.23%in paracancer tissues,and the difference was statistically significant(P<0.05).The positive expression rate of Mina53 in gallbladder cancer tissues of gallbladder cancer patients with different invasion depth,lymph node metastasis,liver metastasis,differentiation degree,TNM stage,nerve invasion and vascular invasion were compared,the differences were statistically significant(P<0.05).Conclusion Mina53 is highly expressed specifically in gallbladder cancer,and its expression is related to the invasion depth,differentiation degree,lymph node metastasis,liver metastasis,TNM stage,nerve invasion and vascular invasion.