多模式精细化干预在宫颈癌化疗患者中的应用效果

Application effect of multimodal refined intervention in patients with cervical cancer undergoing chemotherapy

目的探讨多模式精细化干预在宫颈癌化疗患者中的应用效果。方法根据干预方法的不同将90例宫颈癌化疗患者分为常规干预组(n=45,常规干预)和精细化干预组(n=45,多模式精细化干预)。比较两组患者的心理状态[焦虑自评量表(SAS)和抑郁自评量表(SDS)]、生活质量[健康调查简表(SF-36)]、营养指标及不良反应发生情况。结果干预后,两组患者SAS、SDS评分均低于本组干预前,精细化干预组患者SAS、SDS评分均低于常规干预组,差异均有统计学意义(P﹤0.05)。干预后,两组患者SF-36各维度评分均高于本组干预前,精细化干预组患者SF-36各维度评分均高于常规干预组,差异均有统计学意义(P﹤0.05)。干预后,两组患者白蛋白、血红蛋白水平均高于本组干预前,精细化干预组患者白蛋白、血红蛋白水平均高于常规干预组,差异均有统计学意义(P﹤0.05)。精细化干预组患者恶心呕吐、骨髓抑制、脱发、白细胞/血小板减少发生率均低于常规干预组,差异均有统计学意义(P﹤0.05)。结论多模式精细化干预可有效改善宫颈癌化疗患者的心理状态和营养指标,提高生活质量,降低不良反应发生率。

Objective To investigate the application effect of multimodal refined intervention in patients with cervical cancer undergoing chemotherapy.Method A total of 90 cervical cancer patients undergoing chemotherapy were divided into routine intervention group(n=45,routine intervention)and refined intervention group(n=45,multimodal refined intervention)according to different intervention methods.The psychological state[self-rating anxiety scale(SAS)and self-rating depression scale(SDS)],quality of life[the MOS 36-item short form health survey(SF-36)],nutritional indicators,and adverse events were compared between the two groups.Result After the intervention,the SAS and SDS scores in the two groups were lower than those before the intervention,and the SAS and SDS scores in the refined intervention group were lower than those in the routine intervention group,and the differences were statistically significant(P<0.05).After the intervention,the scores of each dimension of SF-36 in the two groups were higher than those before the intervention,and the scores of each dimension of SF-36 in the refined intervention group were higher than those in the routine intervention group,and the differences were statistically significant(P<0.05).After the intervention,the levels of albumin and hemoglobin in the two groups were higher than those before the intervention,and the levels of the two indicators in the refined intervention group were higher than those in the routine intervention group,and the differences were statistically significant(P<0.05).The incidences of nausea and vomiting,bone marrow supression,alopecia,and leukopenia/thrombocytopenia in the refined intervention group were lower than those in the routine intervention group,and the differences were statistically significant(P<0.05).Conclusion Multimodal refined intervention could effectively improve the psychological state and nutritional indicators of cervical cancer chemotherapy patients,improve the quality of life,and reduce the incidence of adverse events.