某妇幼保健院352例新的/严重的药品不良反应报告分析

Analysis of 352 Reports of New and Serious Adverse Drug Reactions in a Maternal and Child Health Hospital

目的对妇幼保健院2019年至2023年所发生的352例新的/严重的药品不良反应(ADR)进行分析,以弥补说明书的滞后,为患者安全用药提供参考。方法通过国家药品不良反应监测系统回顾性调取某妇幼保健院2019年1月1日至2023年09月30日的352例新的/严重的不良反应报告,使用Excel软件分析其详细情况并总结。结果上报成功的新的/严重的ADR报告共352例,患者年龄为(31.80±15.95)岁,女性为主(310例,88.07%),给药途径以口服为主(138例,39.20%),累及器官-系统以消化系统为主(27.02%);多数表现为恶心、呕吐、嗳气、腹泻、胀气和腹痛等,其次为皮肤及皮下组织类,表现为皮疹、瘙痒和皮肤潮红等。结论临床医师和药师用药期间应密切关注新的/严重的ADR,做好应对措施,保障用药安全。

OBJECTIVE 352 cases of new/serious adverse reactions occurred i n Maternal and Child Health Hospital from 2019 to 2023 were analyzed to make up for the lag of instructions and provide references for safe drug use for patient s.METHODS New/serious drug adverse reaction reports from a maternal and child health hospital between 2019 and 2023 were retrospectively c ollected through the national Adverse drug reaction monitoring system.R ESULTS A total of 352 certified new/serious ADR reports were reported,the patients were(31.80±15.95)years old,mainly female(310 cases,88.07%),the main route of administration was oral(138 cases,39.20%),and the organ-s ystem involved was mainly digestive system(27.02%).Most of the manifestations were nausea,vomiting,belching,diarrhea,gas and abdominal pain,followed by skin and subcutaneous tissue,manifested as rash,pruritus and skin flushing.CONCLUSION Clinicians and pharmacists should pay close attention to new/serious ADRs during drug use,and take appropriate countermeasures to ens ure drug safety.