爱全乐联合普米可令舒吸入治疗对重症肺炎患者血气指标及血清APC、IL-18水平的影响

Effects of Atrovent Combined with Pulmicort on Blood Gas Indexes,Serum APC and IL-18 in Patients with Severe Pneumonia

探究爱全乐联合普米可令舒吸入治疗对重症肺炎患者血气指标及血清活化蛋白C(APC)、白细胞介素-18(IL-18)水平的影响。选择2020年2月至2023年2月本院收治的重症肺炎患者184例随机分成观察组(n=92)及对照组(n=92),对照组采用常规治疗方式,观察组在对照组基础上采用爱全乐联合普米可令舒吸入治疗。比较两组各症状消失时间及不良反应发生率,比较治疗前、后两组的血气指标、肺功能[用力肺活量(FVC)/1s用力呼气容积(FEV1)、峰值呼气流速(PEF)、最大呼吸中期流速(MMF)]及APC、IL-18的变化。治疗后,观察组的止咳时间、痰消时间、肺啰音消失时间、肺部阴影消失时间均低于对照组(P<0.05);治疗后,两组的PaCO_(2)、IL-18水平均低于治疗前,且观察组低于对照组(P<0.05);两组的PaO_(2)、SpO_(2)、FEV1/FVC、MMF、PEF、APC水平均高于治疗前,且观察组高于对照组(P<0.05);两组不良反应发生率分别为11.96%、9.78%,差异无统计学意义(P>0.05)。爱全乐联合普米可令舒吸入治疗能缩短重症肺炎患者临床症状消失时间,改善血气指标及肺部功能,促进APC、IL-18水平改善,且具有一定安全性。

To explore the effects of Atrovent combined with Pulmicort on blood gas indexes,serum activated protein C(APC)and interleukin-18(IL-18)in patients with severe pneumonia,a total of 184 patients with severe pneumonia admitted to the hospital were enrolled and randomly divided into observation group(n=92)and control group(n=92)between February 2020 and February 2023.The control group was given routine treatment,while observation group was additionally treated with Atrovent and Pulmicort.The disappearance time of symptoms and the incidence of adverse reactions,changes of blood gas indexes,lung function indexes[forced vital capacity(FVC)/forced expiratory volume in 1 second(FEV1),peak expiratory flow(PEF),maximum mid-respiratory flow(MMF)],APC and IL-18 before and after treatment were compared between the two groups.After treatment,disappearance time of cough,expectoration,lung rales and lung shadow in observation group were shorter than those in control group(P<0.05).After treatment,PaCO_(2) and IL-18 in both groups were decreased,which were lower in observation group than those in control group(P<0.05),while levels of PaO_(2),SpO_(2),FEV1/FVC,MMF,PEF and APC were increased,which were higher in observation group than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(11.96%vs 9.78%,P>0.05).Atrovent combined with Pulmicort can shorten disappearance time of clinical symptoms,improve blood gas indexes,lung function,APC and IL-18 levels in patients with severe pneumonia,with certain safety.