甲状腺相关激素与2型糖尿病合并牙髓炎的相关性研究

Study on the correlation between thyroid related hormones and pulpitis in type 2 diabetes mellitus

目的 探讨甲状腺相关激素与2型糖尿病(T2DM)合并牙髓炎的关系。方法 2016年8月—2021年12月于该院就诊的T2DM患者中随机选取单纯2型糖尿病组(对照组)59例、T2DM合并牙髓炎(牙髓炎组)50例。比较二组间一般临床生化指标、甲状腺相关激素指标及急性时相反应蛋白(hs-CRP)水平,采用Pearson相关性分析三碘甲状腺原氨酸(T3)、甲状腺素(T4)及游离甲状腺素(FT4)与各项差异指标的相关性,分析T3、T4及FT4三分位分组情况下牙髓炎患病情况,并行多因素Logistic回归分析T2DM合并牙髓炎影响因素。结果 二组间年龄、收缩压(SBP)、舒张压(DBP)、糖尿病(DM)病程、空腹胰岛素(FIns)、白细胞计数(WBC)水平比较,差异有统计学意义(P<0.05)。与对照组比较,牙髓炎组T3、T4及FT4水平降低(P<0.05),hs-CRP水平显著上升(P<0.01)。Pearson相关性分析结果显示,T3与DBP呈负相关,T4与SBP、DBP、WBC呈负相关,FT4与FIns呈负相关(P<0.05)。不同T4水平牙髓炎患病率差异有统计学意义,随T4水平增加呈降低趋势(P<0.05)。DM病程、T4和FIns是T2DM合并牙髓炎的危险因素。结论 T4与SBP、DBP、WBC呈负相关,DM病程、T4和FIns是T2DM合并牙髓炎的危险因素,T4水平检测对辅助诊断T2DM合并牙髓炎具有重要价值。

Objective To investigate the relationship between thyroid related hormones and pulpitis in type 2 diabetes mellitus(T2DM). Methods Among T2DM patients admitted to our hospital from August 2016 to December 2021, 59 cases were randomly selected in the simple type 2 diabetes group(control group) and 50 cases with T2DM combined pulpitis(pulpitis group). The general clinical biochemical indexes, thyroid-related hormone indexes and CRP levels were compared between groups. Pearson correlation was used to analyze the correlation between T3, T4 and FT4 and various difference indexes, and the incidence of pulpitis in the T3, T4 and FT4 triquiles were analyzed, and multivariate logistic regression analysis was performed.Results There were statistically significant differences in age, SBP, DBP, DM course, FIns and WBC levels among groups(P<0.05). Compared with the control group, the levels of T3, T4 and FT4 in pulpitis group were decreased(P<0.05), and CRP level was significantly increased(P<0.01). Pearson correlation analysis showed that T3 was negatively correlated with DBP, T4 was negatively correlated with SBP, DBP and WBC, and FT4 was negatively correlated with FIns(P<0.05). The prevalence of pulpitis at different T4 levels had statistical difference, and showed a decreasing trend with the increase of T4 level(P<0.05). DM course, T4 and FIns are risk factors for T2DM combined pulpitis. Conclusion T4 was negatively correlated with SBP, DBP and WBC. DM course, T4 and FIns are risk factors for T2DM with pulpitis. T4 level detection is of great value in assisting diagnosis of T2DM with pulpitis.