乙型肝炎病毒相关肝胆管细胞癌起源细胞的研究进展

Research progress of origin cells of hepatitis B virus-associated intrahepatic cholangiocarcinoma

肝胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)作为原发性肝癌的一种类型,存在治疗方式局限、治疗效果差等特点,近年来,其发病率和死亡率呈上升趋势。目前ICC起源尚未完全明确。越来越多研究认为,乙型肝炎病毒(hepatitis B virus,HBV)感染是导致ICC的危险因素之一。既往已有研究证实,肝细胞可作为ICC的起源细胞,HBV相关ICC的临床病理特征与肝细胞来源的肝细胞癌(hepatocellular carcinoma,HCC)相似,且部分治疗HCC的方式也可用于治疗HBV相关ICC。本文旨在综述HBV相关ICC起源细胞的研究进展。

As a type of primary liver cancer,intrahepatic cholangiocarcinoma(ICC)has the characteristics of limited treatment and poor therapeutic effect.In recent years,the morbidity and mortality are on the rise.At present,the origin of ICC is not completely clear.More and more studies suggest that hepatitis B virus(HBV)infection is one of the risk factors for ICC.Previous studies have confirmed that hepatocytes can be used as the origin cells of ICC.The linicopathological characteristics of HBV-associated ICC are similar to those of hepatocellular carcinoma(HCC)derived from hepatocytes,and some treatments for HCC can also be used to treat HBV-associated ICC.This article aims to review the research progress of HBV-related ICC-derived cells.