EBV感染与口腔扁平苔藓发病的相关性

The magnitude of the association between Epstein-Barr virus infection and oral lichen planus

目的 系统评价EB病毒(Epstein-Barr virus, EBV)在口腔扁平苔藓(oral lichen planus, OLP)疾病中的总体风险,为临床治疗和预防OLP提供依据。方法 对自建库以来至2023年7月31日的中英文出版物进行数据库检索,纳入符合条件的病例对照研究或横断面研究同时进行文献质量评价,使用RevMan 5软件对纳入文献进行荟萃分析。根据异质性,使用固定效应或随机效应模型估算比值比(OR)和95%置信区间(95%CI),以确定EBV感染与OLP之间的关联。利用漏斗图分析评估发表偏倚。结果 共纳入9项病例对照研究,涉及438名OLP患者以及294名健康对照者。分析发现:EBV与OLP存在显著的相关性,OR值为4.72(95%CI:3.06~7.29),Z值集合效应为6.99(P<0.001);EBV与OLP的相关性存在显著的地区人群差异。结论 EBV与OLP显著相关,其强度可能受到地理和人口因素的影响。

Objective To systematically evaluate the overall risk of Epstein-Barr virus(EBV)in oral lichen planus(OLP)disease to provide a basis for the clinical treatment and prevention of OLP.Methods A database search was conducted for publications in both Chinese and English from the inception of the database until July 31,2023.Case-control studies or cross-sectional studies that met the eligibility criteria were included,and the quality of the literature was assessed.The RevMan 5 software was used to perform a Meta-analysis of the included literature.The pooled odds ratio(OR)and 95%confidence interval(95%CI)were estimated to determine the association between EBV infection and OLP using a fixed-or random-effects model based on heterogeneity.Publication bias was assessed using funnel plot analysis.Results A total of 9 case-control studies were included,involving 438 patients with OLP and 294 healthy controls.The Meta-analysis demonstrated a significant association between Epstein-Barr virus(EBV)infection and OLP,with an OR value of 4.72(95%CI:3.06-7.29),and the combined effect Z-value is 6.99(P<0.001).There is a significant geographical population difference in the correlation between EBV and OLP.Conclusions The results of the current Meta-analysis suggest that EBV infection is statistically associated with increased risk of OLP.The strength of the association may be influenced by geographical and population factors.