外周血环状RNA在消化道肿瘤诊断中的临床应用价值研究

Clinical application of peripheral blood circular RNA in the diagnosis of gastrointestinal tumors

环状RNA(circRNA)是近年新型非编码RNA分子,其结构共价闭环,circRNA参与肿瘤发展各个进程,如肿瘤血管生成、上皮-间质转化(EMT)、耐药、侵袭等。CircRNA会以外泌体、微泡等形式进入血液循环,且不易被核酸酶降解,在血液循环中能够稳定存在。消化道肿瘤发生发展的进程与外周血circRNA的表达水平密切相关,外周血circRNA可能是消化道肿瘤潜在新型的非侵入性的诊断标志物。该文就circRNA在消化道肿瘤诊断价值的研究进展作一综述,着重分析外周血circRNA在消化道肿瘤诊断中的临床应用价值。

Circular RNA(circRNA)is a new type of non-coding RNA molecule with covalent closed-loop structure.CircRNA is involved in various processes of tumor development,such as tumor angiogenesis,epithelial-mesenchymal transformation(EMT),drug resistance,invasion,etc.CircRNA could enter the blood circulation in the form of exosomes and microvesicles,and is not easily degraded by nuclease,and could exist stably in the blood circulation.The progression of gastrointestinal tumors is closely related to the expression level of circRNA in peripheral blood,and peripheral blood circRNA may be a potential novel non-invasive diagnostic marker for gastrointestinal tumors.This article reviews the research progress of circRNA in the diagnosis of gastrointestinal tumors,focusing on the clinical application value of peripheral blood circRNA in the diagnosis of gastrointestinal tumors.