纳米药物递送系统在肺部吸入给药中的研究进展

Advances of Nano Drug Delivery Systems in Pulmonary Inhalation Administration

肺部吸入给药因生物利用度高、患者依从性好等优点,在治疗肺部疾病乃至发挥全身治疗方面展现出较大的临床应用价值。然而,肺部特殊的生理构造使得药物的递送存在多重屏障。纳米药物递送系统因具有独特的优势,被广泛应用于肺部吸入给药。文章详细介绍了阻碍药物转运的肺部吸入给药屏障以及几种吸入型纳米药物递送系统,以期为肺部吸入制剂的临床研究提供参考。

Due to its high bioavailability and good patient compliance,pulmonary inhalation administration has demonstrated significant clinical application value in the treatment of lung disorders and even plays a role in systemic therapy.However,there are numerous obstacles to drug delivery because of the unique physiological structures of the lungs.Nano drug delivery system has been widely used in pulmonary inhalation administration for its special benefits.This paper suminarizes the pulmonary drug delivery barriers and several inhalable nano drug delivery systems in detail,in order to provide reference for future clinical studies of pulmonary inhalation preparation.