原发性高血压患者MHR、MPV及心电图新标准与左心室肥厚的相关性

The correlation between the new standard of MHR,MPV and ECG and left ventricular hypertrophy in patients with essential hypertension

目的探究原发性高血压(EH)患者单核细胞与高密度脂蛋白胆固醇比值(MHR)、平均血小板体积(MPV)及心电图新标准与左心室肥厚(LVH)的关系。方法分析2021年2月至2023年12月期间于南京市第二医院就诊的100例EH患者资料,通过左心室质量指数(LVMI)将其分为伴发左心室肥厚组(LVH组,38例)和未伴发左心室肥厚组(非LVH组,62例)。比较2组患者一般资料、MHR、MPV及心电图新标准(SD+SV4),采用Pearson相关性及二元Logistic回归分析MHR、MPV、SD+SV4与EH患者LVMI的关系及EH患者伴发LVH的影响因素,绘制受试者工作特征(ROC)曲线分析MHR、MPV、SD+SV4对EH患者伴发LVH的预测效能。结果与非LVH组患者比较,LVH组患者高血压病程、BMI、收缩压、WBC、NE、单核细胞、LVMI、MHR、MPV、SD+SV4水平更高,差异有统计学意义(P<0.05);MHR、MPV、SD+SV4与EH患者LVMI均呈正相关(P<0.05);高血压病程、收缩压、MHR、MPV、SD+SV4均是EH患者发生LVH的独立危险因素(P<0.05);MHR、MPV、SD+SV4联合检测以诊断EH患者发生LVH的曲线下面积为0.939,优于单一检测(P<0.05)。结论MHR、MPV及心电图新标准SD+SV4是原发性高血压患者发生LVH的影响因素,三者联合检测对诊断LVH具有较好的预测价值。

Objective To investigate the relationship between the monocyte to high-density lipoprotein cholesterol ratio(MHR),mean platelet volume(MPV),the new ECG standard and left ventricular hypertrophy(LVH)in patients diagnosed with essential hypertension(EH).Methods Data from 100 EH patients admitted to Nanjing Second Hospital from February 2021 to December 2023 were retrospectively analyzed.The patients were divided into two groups:those with left ventricular hypertrophy(LVH group,38 cases)and those without LVH group(non-LVH group,62 cases)based on left ventricular mass index(LVMI).General data,MHR,MPV,and a new standard of electrocardiogram(SD+SV4)were compared between the two groups.Pearson correlation and binary logistic regression were used to analyze the relationship between MHR,MPV,SD+SV4 and LVMI in EH patients and the influencing factors of LVH in EH patients.Receiver operating characteristic(ROC)curves were drawn to analyze the predictive efficacy of MHR,MPV,SD+SV4 in EH patients with LVH.Results Compared with patients without LVH,the levels of hypertension duration,BMI,systolic blood pressure,WBC,NE,monocyte,LVMI,MHR,MPV,SD+SV4 in LVH group were higher,the difference was statistically significant(P<0.05);MHR,MPV,SD+SV4 were positively correlated with LVMI in EH patients(P<0.05).Hypertension duration,systolic blood pressure,MHR,MPV,SD+SV4 were independent risk factors for LVH in EH patients(P<0.05).The area under the curve of MHR,MPV,SD+SV4 combined detection to diagnose LVH in EH patients was 0.939,which was better than that of single detection(P<0.05).Conclusion MHR,MPV and the new ECG standard SD+SV4 are influential factors in the development of LVH in patients with essential hypertension.The combined detection of MHR,MPV,and SD+SV4 has shown to have good predictive value for diagnosing LVH.