超声多参数成像技术联合血清OPG、RANKL水平检测及骨密度评估在冻结肩患者骨代谢状态分析中的应用价值

The application value of ultrasonic multi-parameter imaging technology combined with serum OPG,RANKL level detection and bone mineral density evaluation in the analysis of bone metabolism status in patients with frozen shoulder

目的通过超声多参数成像联合血清OPG、RANKL水平检测及骨密度评估,综合探讨冻结肩患者的骨代谢状态。方法选取2022年1月至2024年1月于宝鸡高新医院就诊的124例冻结肩患者作为研究对象。根据骨密度测定结果分为三组,A组(骨量正常组,n=37):T值≥-1.0、B组(骨量减少组,n=51):T值在-2.5至-1.0之间;C组(骨质疏松组,n=36):T值≤-2.5。另选取同期于本院体检的61名健康者作为对照组。比较四组一般资料、超声多参数成像、血清OPG、RANKL及T值,采用ROC曲线分析超声多参数成像联合血清OPG、RANKL及T值评估冻结肩患者骨代谢状态的价值。结果四组性别、年龄、BMI、WHR比较,差异无统计学意义(P>0.05)。肌肉厚度、肌腱厚度、血流速度、T值比较:对照组>A组>B组>C组,差异有统计学意义(P<0.05);关节囊厚度、RI、血清OPG、RANKL比较:对照组<A组<B组<C组,差异有统计学意义(P<0.05)。超声多参数成像联合血清OPG、RANKL及T值评估冻结肩患者骨代谢状态的AUC(95%CI)、敏感度及特异度分别为0.905、87.66%及90.17%,均显著高于超声多参数成像、血清OPG、RANKL及T值单一检测(P<0.05)。结论超声多参数成像联合血清OPG、RANKL及骨密度评估冻结肩患者骨代谢状态具有较高的应用价值,能够提高诊断的准确性和敏感性,为临床医生提供更全面的患者信息,有助于制定更加个性化和精准的治疗方案。

Objective To explore the bone metabolism status of frozen shoulder patients through ultrasonic multi-parameter imaging combined with serum OPG,RANKL level detection and bone mineral density evaluation.Methods A total of 124 patients with frozen shoulders who were treated at Baoji High-tech Hospital from January 2022 to January 2024 were selected as the study subjects.Based on the results of bone mineral density measurement,they were divided into three groups:group A(normal bone mass group,n=37):T value≥-1.0,group B(osteopenia group,n=51):T value between-2.5 and-1.0;group C(osteoporosis group,n=36):T value≤-2.5.In addition,61 healthy people who underwent physical examinations in our hospital during the same period were selected as the control group.The general data,ultrasonic multi-parameter imaging,serum OPG,RANKL and T values of the four groups were compared.The ROC curve was used to analyze the value of ultrasonic multi-parameter imaging combined with serum OPG,RANKL and T values in evaluating bone metabolism in patients with frozen shoulders.Results There were no significant differences in gender,age,BMI and WHR among the four groups(P>0.05).The comparison of muscle thickness,tendon thickness,blood flow velocity,and T-value:Control group>Group A>Group B>Group C,with statistically significant differences(P<0.05).The comparison of joint capsule thickness,RI,serum OPG,and RANKL:Control group<Group A<Group B<Group C,with statistically significant differences(P<0.05).The AUC(95%CI),sensitivity and specificity of ultrasonic multi-parameter imaging combined with serum OPG,RANKL and T values in evaluating bone metabolism in patients with frozen shoulder were 0.905,87.66%and 90.17%,respectively,which were significantly higher than those of ultrasonic multi-parameter imaging,serum OPG,RANKL and T values anlone(P<0.05).Conclusion Ultrasound multi-parameter imaging combined with serum OPG,RANKL and bone mineral density has high application value in evaluating the bone metabolism status of patients with frozen shoulders.This approach can not only improve the accuracy and sensitivity of diagnosis,but also provide clinicians with more comprehensive patient information.This,in turn,helps in formulating more personalized and accurate treatment plans.