烟酰胺单核苷酸在抗衰老和衰老相关疾病治疗中的作用研究进展

Research progress on the role of nicotinamide mononucleotide(NMN)in anti-aging and treatment of aging-associated diseases

烟酰胺腺嘌呤二核苷酸(NAD^(+))作为氧化还原反应的辅酶在能量代谢中发挥重要作用,也是非氧化还原NAD+依赖酶的必要共底物。NAD^(+)广泛参与能量代谢、DNA修复、细胞衰老、表观遗传等多种细胞生物学过程,与衰老及其相关疾病密切相关。近年研究表明,补充NAD^(+)的前体烟酰胺单核苷酸(NMN)可以提高NAD^(+)水平,在与年龄相关的多种疾病,如心血管疾病、神经退行性疾病、肾脏疾病、内分泌代谢疾病、生殖系统疾病、恶性肿瘤等方面具有巨大的预防和治疗潜力。本文对NAD^(+)的代谢和NMN在减缓衰老及其相关性疾病的研究进展进行综述。

Nicotinamide adenine dinucleotide(NAD^(+)),a coenzyme for redox reactions crucial to energy metabolism,is also a required co-substrate for non-redox NAD^(+)-dependent enzymes.NAD^(+)participates in a wide range of biological functions within cells,including energy metabolism,DNA repair,cellular senescence,and epigenetics.It is also closely correlated with aging and aging-associated disorders.Recent research has indicated that supplementation with nicotinamide mononucleotide(NMN),a precursor of NAD^(+),can increase NAD^(+)levels and has excellent preventive and therapeutic potential in a variety of age-related diseases,such as cardiovascular diseases,neurodegenerative diseases,renal diseases,endocrine and metabolic diseases,reproductive system diseases and malignant tumors.This paper provided a comprehensive review of recent research advances on NAD^(+)metabolism and the role of NMN in anti-aging and aging-associated diseases.