老年人炎症性肠病发病机制的研究进展与干细胞治疗

Research progress on pathogenesis of inflammatory bowel disease and stem cell therapy in the elderly

随着中国步入老龄化时代,老年人炎症性肠病(IBD)的患病率较前升高,衰老与炎症的联系似乎在老年IBD患者中更加显著。然而,目前的研究大多侧重于对其临床特点的描述,针对发病机制的探讨较少。本文总结了老年人IBD与青年人IBD的临床特征和治疗差异,深入探讨了衰老对老年人IBD发病可能的影响和干细胞移植疗法在老年人IBD治疗中的可能性,旨在为老年人IBD的临床研究提供新的思路。

As China enters the aging era,the incidence rate and prevalence of inflammatory bowel disease(IBD)in the elderly have increased.The relationship between aging and inflammation appears to be more significant in elderly individuals with IBD.However,most current studies focus on describing the clinical characteristics of the disease,with limited research on its pathogenesis and treatment.In this review,we summarize the differences in clinical characteristics and treatment between elderly individuals with IBD and young individuals.We also discuss the impact of aging on elderly IBD and explore the possibility of stem cell transplantation therapy as a new approach for clinical management.Our aim is to provide fresh insights for the treatment of elderly IBD.